Detailed information of TA system TA186906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1138603..1139222
• Replicon: chromosome
• Accession: NZ_CP068234
• Organism: Leclercia adecarboxylata strain YZ30

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A345CDT0
• Locus tag: JJN11_RS05370
• Protein ID: WP_032616864.1
• Coordinates: 1138603..1138821 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: JJN11_RS05375
• Protein ID: WP_103178503.1
• Coordinates: 1138830..1139222 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJN11_RS05350 (JJN11_05335)	1135473..1135826	+	354	WP_103178500.1	DUF1428 family protein	-
JJN11_RS05355 (JJN11_05340)	1135859..1137427	-	1569	WP_103178501.1	EAL domain-containing protein	-
JJN11_RS05360 (JJN11_05345)	1137685..1137825	+	141	WP_003859006.1	type B 50S ribosomal protein L36	-
JJN11_RS05365 (JJN11_05350)	1137875..1138339	-	465	WP_156654006.1	YlaC family protein	-
JJN11_RS05370 (JJN11_05355)	1138603..1138821	-	219	WP_032616864.1	HHA domain-containing protein	Toxin
JJN11_RS05375 (JJN11_05360)	1138830..1139222	-	393	WP_103178503.1	Hha toxicity modulator TomB	Antitoxin
JJN11_RS05380 (JJN11_05365)	1139712..1142852	-	3141	WP_103178504.1	multidrug efflux RND transporter permease subunit AcrB	-
JJN11_RS05385 (JJN11_05370)	1142875..1144068	-	1194	WP_156654007.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1128834..1139222	10388

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-115)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8583.95 Da
• Isoelectric Point: 8.9008

>T186906 WP_032616864.1 NZ_CP068234:c1138821-1138603 [Leclercia adecarboxylata]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Nucleotide

• Length: 219 bp

>T186906 NZ_CP089774:2255679-2256077 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 15150.05 Da
• Isoelectric Point: 4.8941

>AT186906 WP_103178503.1 NZ_CP068234:c1139222-1138830 [Leclercia adecarboxylata]
MDEYSPKRQDIAQLKFLCESLYHDCLTNLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNASRANPLASPIKIITNN

Nucleotide

• Length: 393 bp

>AT186906 NZ_CP089774:2255451-2255678 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Structures

Toxin

• AlphaFold DB: A0A345CDT0