Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 549249..549765 Replicon chromosome
Accession NZ_CP068234
Organism Leclercia adecarboxylata strain YZ30

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JJN11_RS02645 Protein ID WP_156653790.1
Coordinates 549481..549765 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JJN11_RS02640 Protein ID WP_103178029.1
Coordinates 549249..549491 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJN11_RS02625 (JJN11_02630) 545310..546050 + 741 WP_103178026.1 KDGP aldolase family protein -
JJN11_RS02630 (JJN11_02635) 546105..547241 + 1137 WP_156653788.1 lactonase family protein -
JJN11_RS02635 (JJN11_02640) 547261..549171 + 1911 WP_156653789.1 PRD domain-containing protein -
JJN11_RS02640 (JJN11_02645) 549249..549491 + 243 WP_103178029.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JJN11_RS02645 (JJN11_02650) 549481..549765 + 285 WP_156653790.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JJN11_RS02650 (JJN11_02655) 549769..550233 - 465 WP_156653791.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JJN11_RS02655 (JJN11_02660) 550340..552478 - 2139 WP_156653792.1 anaerobic ribonucleoside-triphosphate reductase -
JJN11_RS02660 (JJN11_02665) 552849..554504 - 1656 WP_156653793.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10840.65 Da        Isoelectric Point: 10.5826

>T186905 WP_156653790.1 NZ_CP068234:549481-549765 [Leclercia adecarboxylata]
MTYELEFDPRALKEWQKLGDTVKSQFKKKLAVVLSNPRRESARLHGLPGCYKIKLSSSGYRLVYQVRDKVITVFVVAVGK
REKSAVYHDANQRL

Download         Length: 285 bp

>T186905 NZ_CP089774:c2232055-2231711 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9057.44 Da        Isoelectric Point: 5.1088

>AT186905 WP_103178029.1 NZ_CP068234:549249-549491 [Leclercia adecarboxylata]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTVTVSDSEDELIRTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT186905 NZ_CP089774:c2232297-2232049 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References