Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 52258..52920 Replicon chromosome
Accession NZ_CP068234
Organism Leclercia adecarboxylata strain YZ30

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JJN11_RS00260 Protein ID WP_156653663.1
Coordinates 52522..52920 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JJN11_RS00255 Protein ID WP_156653662.1
Coordinates 52258..52518 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJN11_RS00225 (JJN11_00225) 47275..47589 - 315 WP_103177669.1 PTS sugar transporter subunit IIB -
JJN11_RS00230 (JJN11_00230) 47884..48831 + 948 WP_103177670.1 LacI family DNA-binding transcriptional regulator -
JJN11_RS00235 (JJN11_00235) 48868..49164 - 297 WP_103177671.1 YicS family protein -
JJN11_RS00240 (JJN11_00240) 49487..49906 + 420 WP_156653659.1 GNAT family N-acetyltransferase -
JJN11_RS00245 (JJN11_00245) 49903..50562 - 660 WP_156653660.1 TetR/AcrR family transcriptional regulator -
JJN11_RS00250 (JJN11_00250) 50641..52140 + 1500 WP_156653661.1 MDR family MFS transporter -
JJN11_RS00255 (JJN11_00255) 52258..52518 + 261 WP_156653662.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JJN11_RS00260 (JJN11_00260) 52522..52920 + 399 WP_156653663.1 type II toxin-antitoxin system VapC family toxin Toxin
JJN11_RS00265 (JJN11_00265) 53115..53918 + 804 WP_156653664.1 lipoprotein NlpA -
JJN11_RS00270 (JJN11_00270) 54046..54825 + 780 WP_156653665.1 MBL fold metallo-hydrolase -
JJN11_RS00275 (JJN11_00275) 54851..55813 + 963 WP_156653666.1 helix-turn-helix domain-containing protein -
JJN11_RS00280 (JJN11_00280) 55833..56921 - 1089 WP_156653667.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14665.76 Da        Isoelectric Point: 5.4732

>T186902 WP_156653663.1 NZ_CP068234:52522-52920 [Leclercia adecarboxylata]
MLHMLDTNIVSHLVRQHPGVVNHYSRLAPEDMCISSVTEAELLYGVAKKQSLRLHETISEFLKTITVCDWDSDAAAIYGK
LRAEMEKHGKVMGDLDQLIAAHAISRGTTIVTNDQAFAMVQELTVEDWTTAA

Download         Length: 399 bp

>T186902 NZ_CP089774:c2201382-2201086 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10222.60 Da        Isoelectric Point: 9.8083

>AT186902 WP_156653662.1 NZ_CP068234:52258-52518 [Leclercia adecarboxylata]
MERKAKLFKKGRNQAVLLPAEFAFDAESVWIRRDEEGNVVLRAMSEKERHRENFLRLLKQTHVPDSFLSKEERNQSYTTR
DPFEGL

Download         Length: 261 bp

>AT186902 NZ_CP089774:c2201630-2201379 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References