Detailed information of TA system TA186901

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ygfYX/Cpta(toxin)
• Location: 3542779..3543421
• Replicon: chromosome
• Accession: NZ_CP068230
• Organism: Shewanella algae strain CECT 5071

Toxin (Protein)

• Gene name: ygfX
• Uniprot ID: A0A5N5U1D5
• Locus tag: E1N14_RS15875
• Protein ID: WP_025010549.1
• Coordinates: 3542779..3543201 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: ygfY
• Uniprot ID: A0A5N5U1J5
• Locus tag: E1N14_RS15880
• Protein ID: WP_062793819.1
• Coordinates: 3543182..3543421 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1N14_RS15850	3538297..3538776	-	480	WP_025010554.1	SoxR reducing system RseC family protein	-
E1N14_RS15855	3538787..3539719	-	933	WP_025010553.1	MucB/RseB C-terminal domain-containing protein	-
E1N14_RS15860	3539729..3540349	-	621	WP_025010552.1	anti-sigma factor	-
E1N14_RS15865	3540374..3540952	-	579	WP_025010551.1	RNA polymerase sigma factor RpoE	-
E1N14_RS15870	3541151..3542761	+	1611	WP_025010550.1	L-aspartate oxidase	-
E1N14_RS15875	3542779..3543201	-	423	WP_025010549.1	hypothetical protein	Toxin
E1N14_RS15880	3543182..3543421	-	240	WP_062793819.1	succinate dehydrogenase assembly factor 2	Antitoxin
E1N14_RS15885	3543520..3544428	-	909	WP_025010548.1	transcriptional activator NhaR	-
E1N14_RS15890	3544445..3544813	-	369	WP_096141176.1	hypothetical protein	-
E1N14_RS15895	3544825..3546000	-	1176	WP_025010547.1	Na+/H+ antiporter NhaA	-
E1N14_RS15900	3546117..3546911	-	795	WP_025010546.1	thymidylate synthase	-
E1N14_RS15905	3546911..3547738	-	828	WP_025010545.1	prolipoprotein diacylglyceryl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-135)

Antitoxin

• Flavinator of succinate dehydrogenase (5-75)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16309.86 Da
• Isoelectric Point: 7.0359

>T186901 WP_025010549.1 NZ_CP068230:c3543201-3542779 [Shewanella algae]
VAGQRHRFQLSSSFSQYLSLTVLAAICLSSFLAWPALDYPFYLLFKYLCLLLMLAGFGLALWRLRCWQLCFWLNELGEGQ
FEPGSSFELSGRPWVSPFVVTFTYQGEDNYGRCWLFADMFDDTDYRHLCRLLLQRSKSAN

Nucleotide

• Length: 423 bp

>T186901 NZ_CP089774:2199124-2199501 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9237.70 Da
• Isoelectric Point: 5.0633

>AT186901 WP_062793819.1 NZ_CP068230:c3543421-3543182 [Shewanella algae]
MSTPRVKWACRRGMLELDVLFQPFVEQHYETLSPEDKALFVRLLECEDPELFAWFMGHEQCSDPQLAQMVVRVRGRAAP

Nucleotide

• Length: 240 bp

>AT186901 NZ_CP089774:2199543-2199992 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA