Detailed information of TA system TA186900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1092459..1093604
• Replicon: chromosome
• Accession: NZ_CP068230
• Organism: Shewanella algae strain CECT 5071

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A5N5TWA9
• Locus tag: E1N14_RS04910
• Protein ID: WP_025011539.1
• Coordinates: 1092858..1093604 (+)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7X5Z3H2
• Locus tag: E1N14_RS04905
• Protein ID: WP_025011540.1
• Coordinates: 1092459..1092821 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1N14_RS04890	1089922..1090659	-	738	WP_025011543.1	DsbA family protein	-
E1N14_RS04895	1090800..1091441	-	642	WP_025011542.1	DnaJ domain-containing protein	-
E1N14_RS04900	1091572..1092225	-	654	WP_025011541.1	oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB	-
E1N14_RS04905	1092459..1092821	+	363	WP_025011540.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
E1N14_RS04910	1092858..1093604	+	747	WP_025011539.1	RES family NAD+ phosphorylase	Toxin
E1N14_RS04915	1093618..1095183	-	1566	WP_062794000.1	hypothetical protein	-
E1N14_RS04920	1095282..1096007	-	726	WP_025011538.1	amino acid ABC transporter ATP-binding protein	-
E1N14_RS04925	1096000..1096677	-	678	WP_025011537.1	amino acid ABC transporter permease	-
E1N14_RS04930	1096684..1097409	-	726	WP_025011536.1	basic amino acid ABC transporter substrate-binding protein	-
E1N14_RS04935	1097821..1098387	+	567	WP_025011535.1	hypoxanthine phosphoribosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (55-205)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-118)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 28898.66 Da
• Isoelectric Point: 4.6921

>T186900 WP_025011539.1 NZ_CP068230:1092858-1093604 [Shewanella algae]
MDFSALEPQDFFPRPYLGRGYRLVESQEEAATLSLVDDFDEQMLLESLLDEVKPPYRSGTEHLHYLLKTPFRYPPLRHGS
RFGSITMESFFYASESWQTCLAEVAYYRFVFMADMLEPYLEPLRSEHMLYSVDINARDCADLTLLQGREVQQQLTHKSNY
TYTQAMGAWLLQQQAQMIRYTSARAEEGVNLALHDPLVLQSTEPQECEYWICQSSADKVAFSRRNSRSMPLTWFLKDFLQ
DGQLPRPA

Nucleotide

• Length: 747 bp

>T186900 NZ_CP089774:c2192378-2192049 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13125.14 Da
• Isoelectric Point: 10.4675

>AT186900 WP_025011540.1 NZ_CP068230:1092459-1092821 [Shewanella algae]
MNTLEKANAAEVLFKAFSNACSELQLTQAEASRIIGVNPSTLSRNSGKGFKPDSKQGELQLQLIRLYRSLYAIAGGEKAF
MRHWLNSPNKALNGTPKTLLQTVVGLVSVNQYLDAMRGKV

Nucleotide

• Length: 363 bp

>AT186900 NZ_CP089774:c2192752-2192375 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z3H2