Detailed information of TA system TA186899

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 772215..773764
• Replicon: chromosome
• Accession: NZ_CP068230
• Organism: Shewanella algae strain CECT 5071

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A5N5TVN9
• Locus tag: E1N14_RS03590
• Protein ID: WP_062793729.1
• Coordinates: 772215..773516 (-)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: E1N14_RS03595
• Protein ID: WP_025011264.1
• Coordinates: 773516..773764 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1N14_RS03575	767715..768299	+	585	WP_062793730.1	LysE family translocator	-
E1N14_RS03580	768376..770403	-	2028	WP_025011266.1	S9 family peptidase	-
E1N14_RS03585	770707..772074	+	1368	WP_025011265.1	L-cystine transporter	-
E1N14_RS03590	772215..773516	-	1302	WP_062793729.1	type II toxin-antitoxin system HipA family toxin	Toxin
E1N14_RS03595	773516..773764	-	249	WP_025011264.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
E1N14_RS03600	774277..775968	+	1692	WP_025011263.1	ATP-binding cassette domain-containing protein	-
E1N14_RS03605	775979..776353	-	375	WP_014386412.1	PH domain-containing protein	-
E1N14_RS03610	776364..778289	-	1926	WP_025011262.1	U32 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-64)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 48696.41 Da
• Isoelectric Point: 9.1869

>T186899 WP_062793729.1 NZ_CP068230:c773516-772215 [Shewanella algae]
MQKLIAYMNGELVGTLAKHKNGAHTFQYDKDWITNAMTRPLSLSLRLQLPTITSDAVINYFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGKDSVGAIALFPPEHPYKKEPLSYEILDNKKLEAVLSAYKSDIPLGMLKEEEDFRISVAGAQEKTAL
LFIDGQWCIPKGNTPTTHIIKLPIGEIPQANATLDLKDSVENEYLCIELAKALGFAVPSVNIIKTDNLKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIEQIMKLLMGSSNALEDRYNFMRFQVFQWIIGATDGHAKNFSIYID
RGGSYRLTPFYDILSAYPLLGGKGLNIRQLKLAMGLKATKGKKYEINKILPRHFLDTAKAVNFSQDKMQRIMDEMKGALP
EAISQVRANLPEGFPEHISDSIFENANKIIKKI

Nucleotide

• Length: 1302 bp

>T186899 NZ_CP089774:1963025-1963273 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9366.70 Da
• Isoelectric Point: 6.2564

>AT186899 WP_025011264.1 NZ_CP068230:c773764-773516 [Shewanella algae]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLVQAMDLTLSIQEKTQLTSPSENDDE
SW

Nucleotide

• Length: 249 bp

>AT186899 NZ_CP089774:1962813-1963025 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA