Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4254427..4255976 Replicon chromosome
Accession NZ_CP068229
Organism Shewanella algae strain 150735

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JKK46_RS18865 Protein ID WP_101060123.1
Coordinates 4254675..4255976 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JKK46_RS18860 Protein ID WP_025011264.1
Coordinates 4254427..4254675 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKK46_RS18845 (JKK46_18850) 4249887..4251812 + 1926 WP_208128576.1 U32 family peptidase -
JKK46_RS18850 (JKK46_18855) 4251823..4252197 + 375 WP_208128577.1 PH domain-containing protein -
JKK46_RS18855 (JKK46_18860) 4252210..4253913 - 1704 WP_208128578.1 ATP-binding cassette domain-containing protein -
JKK46_RS18860 (JKK46_18865) 4254427..4254675 + 249 WP_025011264.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JKK46_RS18865 (JKK46_18870) 4254675..4255976 + 1302 WP_101060123.1 type II toxin-antitoxin system HipA family toxin Toxin
JKK46_RS18870 (JKK46_18875) 4256117..4257484 - 1368 WP_208128579.1 L-cystine transporter -
JKK46_RS18875 (JKK46_18880) 4257788..4259815 + 2028 WP_208128580.1 S9 family peptidase -
JKK46_RS18880 (JKK46_18885) 4259893..4260477 - 585 WP_044733696.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48617.45 Da        Isoelectric Point: 9.5376

>T186897 WP_101060123.1 NZ_CP068229:4254675-4255976 [Shewanella algae]
MQKLIAYMNGELVGTLAKHKNGAHTFQYDKDWITNAMARPLSLSLRLQLPPITSDAVINYFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGKDSVGAIALFPPEHPYKKEPLSYEILDNKKLEAVLSAYKSDIPLGMLKEEEDFRISVAGAQEKTAL
LFIDGQWCIPKGNTPTTHIIKLPIGEIPQANATLDLKDSVENEYLCIELAKALGFAVPSVNIIKTDNLKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIAQIMKLLMGSSNALEDRYNFMRFQVFQWIIGATDGHAKNFSIYID
RGGSYRLTPFYDILSAYPLLGGKGLNIRQLKLAMGLKATKGKKYEINKILPRHFLDTAKAVNFSQDKMQRIMDEMKGALP
EAISQVRANLPEGFPEHISNSIFENAKKIIKKI

Download         Length: 1302 bp

>T186897 NZ_CP089774:1769381-1769785 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9366.70 Da        Isoelectric Point: 6.2564

>AT186897 WP_025011264.1 NZ_CP068229:4254427-4254675 [Shewanella algae]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLVQAMDLTLSIQEKTQLTSPSENDDE
SW

Download         Length: 249 bp

>AT186897 NZ_CP089774:1769172-1769375 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References