Detailed information of TA system TA186896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 3935570..3936715
• Replicon: chromosome
• Accession: NZ_CP068229
• Organism: Shewanella algae strain 150735

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JKK46_RS17545
• Protein ID: WP_045283715.1
• Coordinates: 3935570..3936316 (-)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7X5Z3H2
• Locus tag: JKK46_RS17550
• Protein ID: WP_025011540.1
• Coordinates: 3936353..3936715 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JKK46_RS17520 (JKK46_17525)	3930787..3931353	-	567	WP_025011535.1	phosphoribosyltransferase family protein	-
JKK46_RS17525 (JKK46_17530)	3931765..3932490	+	726	WP_045283734.1	basic amino acid ABC transporter substrate-binding protein	-
JKK46_RS17530 (JKK46_17535)	3932497..3933174	+	678	WP_025011537.1	amino acid ABC transporter permease	-
JKK46_RS17535 (JKK46_17540)	3933167..3933892	+	726	WP_025886969.1	amino acid ABC transporter ATP-binding protein	-
JKK46_RS17540 (JKK46_17545)	3933991..3935556	+	1566	WP_208128477.1	hypothetical protein	-
JKK46_RS17545 (JKK46_17550)	3935570..3936316	-	747	WP_045283715.1	RES family NAD+ phosphorylase	Toxin
JKK46_RS17550 (JKK46_17555)	3936353..3936715	-	363	WP_025011540.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
JKK46_RS17555 (JKK46_17560)	3936948..3937601	+	654	WP_093982133.1	oxygen-insensitive NAD(P)H nitroreductase	-
JKK46_RS17560 (JKK46_17565)	3937732..3938373	+	642	WP_129979284.1	DNA-J related domain-containing protein	-
JKK46_RS17565 (JKK46_17570)	3938514..3939251	+	738	WP_123115805.1	thioredoxin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (55-205)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-118)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 28826.60 Da
• Isoelectric Point: 4.6800

>T186896 WP_045283715.1 NZ_CP068229:c3936316-3935570 [Shewanella algae]
MDFSALEPQDFFPRPYLGRGYRLVESQEEAATLSLVDDFDEQMLLESLLDEVKPPYRSGTEHLHYLLKTPFRYPPLRHGS
RFGSITMESFFYASESWQTCLAEVAYYRFVFMADMLEPYLEPLRSEHMLYSVDINARDCADLTLLQGQEVQQQLTHKSNY
TYTQAMGAWLLQQQAQMIRYTSARAEEGVNLALHDPLVLQSTEPQECEYWICQSSAAKVAFSRRNSRSMPLTWFLKDFLQ
DGQLPRPA

Nucleotide

• Length: 747 bp

>T186896 NZ_CP089774:1690971-1691288 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13125.14 Da
• Isoelectric Point: 10.4675

>AT186896 WP_025011540.1 NZ_CP068229:c3936715-3936353 [Shewanella algae]
MNTLEKANAAEVLFKAFSNACSELQLTQAEASRIIGVNPSTLSRNSGKGFKPDSKQGELQLQLIRLYRSLYAIAGGEKAF
MRHWLNSPNKALNGTPKTLLQTVVGLVSVNQYLDAMRGKV

Nucleotide

• Length: 363 bp

>AT186896 NZ_CP089774:1690672-1690974 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z3H2