Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
Location | 4142438..4143978 | Replicon | chromosome |
Accession | NZ_CP068228 | ||
Organism | Shewanella algae strain G1 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | JKK44_RS18520 | Protein ID | WP_208165929.1 |
Coordinates | 4142438..4143739 (-) | Length | 434 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | JKK44_RS18525 | Protein ID | WP_025888014.1 |
Coordinates | 4143742..4143978 (-) | Length | 79 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JKK44_RS18490 (JKK44_18485) | 4137632..4137907 | + | 276 | WP_045283442.1 | hypothetical protein | - |
JKK44_RS18495 (JKK44_18490) | 4137957..4138391 | + | 435 | WP_020442396.1 | HNH endonuclease | - |
JKK44_RS18500 (JKK44_18495) | 4138730..4139077 | + | 348 | WP_025011793.1 | hypothetical protein | - |
JKK44_RS18505 (JKK44_18500) | 4139493..4140656 | + | 1164 | WP_208165927.1 | RNA ligase RtcB family protein | - |
JKK44_RS18510 (JKK44_18505) | 4140656..4141291 | + | 636 | WP_145839170.1 | peptide chain release factor H | - |
JKK44_RS18515 (JKK44_18510) | 4141424..4142377 | - | 954 | WP_208165928.1 | tetratricopeptide repeat protein | - |
JKK44_RS18520 (JKK44_18515) | 4142438..4143739 | - | 1302 | WP_208165929.1 | HipA domain-containing protein | Toxin |
JKK44_RS18525 (JKK44_18520) | 4143742..4143978 | - | 237 | WP_025888014.1 | helix-turn-helix domain-containing protein | Antitoxin |
JKK44_RS18530 (JKK44_18525) | 4144187..4144771 | - | 585 | WP_208165930.1 | cold shock domain-containing protein | - |
JKK44_RS18535 (JKK44_18530) | 4144949..4145131 | - | 183 | WP_144226198.1 | cold shock domain-containing protein | - |
JKK44_RS18540 (JKK44_18535) | 4145101..4145343 | + | 243 | WP_208166509.1 | hypothetical protein | - |
JKK44_RS18545 (JKK44_18540) | 4145851..4146435 | + | 585 | WP_208165931.1 | hypothetical protein | - |
JKK44_RS18550 (JKK44_18545) | 4146492..4147613 | + | 1122 | WP_071237152.1 | ISAs1 family transposase | - |
JKK44_RS18555 (JKK44_18550) | 4148263..4148862 | + | 600 | WP_208165932.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 4146492..4147613 | 1121 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 434 a.a. Molecular weight: 48488.32 Da Isoelectric Point: 4.6970
>T186894 WP_208165929.1 NZ_CP068228:c4143739-4142438 [Shewanella algae]
MSGAANLVLDMHLGDRIIGELSFDPATESFAVSYSQDWRQNGFPISPMIPLDGTGSSTQIAMFLGNLLPENRGLDYLIES
LGVSRGNTFALIRAIGLDTAGAVAFSPKGTELPQTAFREISDDEIILRLEEPELWPMEVWDGKPRLSVAGVQSKLNLFYN
GKQFGFGEGALSSTHILKFEKQRHLVINEFLTMRLAKSIAMNVANVEIRHFGQHKSLCVERFDRRYLPAEQRVLRRHIID
SCQALGFSVNKKYERNFGNGRDVRDIREGVSLPRLFALAEQCANPAAAKQDMLQWTLFNLLSGNADAHGKNYSFFMTPTG
MVPTPWYDLVCVALYEEFEQELAMAIDDEFDPDKIYAYQLAAFSEDIGLPRALVSNSLTRMATRISQEIEGVIAMLDGLD
KDEQAFVASYKAQLLARCECYLDIAPQINEMEL
MSGAANLVLDMHLGDRIIGELSFDPATESFAVSYSQDWRQNGFPISPMIPLDGTGSSTQIAMFLGNLLPENRGLDYLIES
LGVSRGNTFALIRAIGLDTAGAVAFSPKGTELPQTAFREISDDEIILRLEEPELWPMEVWDGKPRLSVAGVQSKLNLFYN
GKQFGFGEGALSSTHILKFEKQRHLVINEFLTMRLAKSIAMNVANVEIRHFGQHKSLCVERFDRRYLPAEQRVLRRHIID
SCQALGFSVNKKYERNFGNGRDVRDIREGVSLPRLFALAEQCANPAAAKQDMLQWTLFNLLSGNADAHGKNYSFFMTPTG
MVPTPWYDLVCVALYEEFEQELAMAIDDEFDPDKIYAYQLAAFSEDIGLPRALVSNSLTRMATRISQEIEGVIAMLDGLD
KDEQAFVASYKAQLLARCECYLDIAPQINEMEL
Download Length: 1302 bp
>T186894 NZ_CP089774:1543839-1544660 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8524.09 Da Isoelectric Point: 9.0186
>AT186894 WP_025888014.1 NZ_CP068228:c4143978-4143742 [Shewanella algae]
MVSPLTPHSLGALIKVRRKEAALTLDVAAMLCGVTKKTFIRVEKGEDVYISTVFKILDGLGIHLLAQPKPDVDSTGWY
MVSPLTPHSLGALIKVRRKEAALTLDVAAMLCGVTKKTFIRVEKGEDVYISTVFKILDGLGIHLLAQPKPDVDSTGWY
Download Length: 237 bp
>AT186894 NZ_CP089774:1544653-1544889 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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