Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4142438..4143978 Replicon chromosome
Accession NZ_CP068228
Organism Shewanella algae strain G1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JKK44_RS18520 Protein ID WP_208165929.1
Coordinates 4142438..4143739 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JKK44_RS18525 Protein ID WP_025888014.1
Coordinates 4143742..4143978 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKK44_RS18490 (JKK44_18485) 4137632..4137907 + 276 WP_045283442.1 hypothetical protein -
JKK44_RS18495 (JKK44_18490) 4137957..4138391 + 435 WP_020442396.1 HNH endonuclease -
JKK44_RS18500 (JKK44_18495) 4138730..4139077 + 348 WP_025011793.1 hypothetical protein -
JKK44_RS18505 (JKK44_18500) 4139493..4140656 + 1164 WP_208165927.1 RNA ligase RtcB family protein -
JKK44_RS18510 (JKK44_18505) 4140656..4141291 + 636 WP_145839170.1 peptide chain release factor H -
JKK44_RS18515 (JKK44_18510) 4141424..4142377 - 954 WP_208165928.1 tetratricopeptide repeat protein -
JKK44_RS18520 (JKK44_18515) 4142438..4143739 - 1302 WP_208165929.1 HipA domain-containing protein Toxin
JKK44_RS18525 (JKK44_18520) 4143742..4143978 - 237 WP_025888014.1 helix-turn-helix domain-containing protein Antitoxin
JKK44_RS18530 (JKK44_18525) 4144187..4144771 - 585 WP_208165930.1 cold shock domain-containing protein -
JKK44_RS18535 (JKK44_18530) 4144949..4145131 - 183 WP_144226198.1 cold shock domain-containing protein -
JKK44_RS18540 (JKK44_18535) 4145101..4145343 + 243 WP_208166509.1 hypothetical protein -
JKK44_RS18545 (JKK44_18540) 4145851..4146435 + 585 WP_208165931.1 hypothetical protein -
JKK44_RS18550 (JKK44_18545) 4146492..4147613 + 1122 WP_071237152.1 ISAs1 family transposase -
JKK44_RS18555 (JKK44_18550) 4148263..4148862 + 600 WP_208165932.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4146492..4147613 1121


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(146-387)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48488.32 Da        Isoelectric Point: 4.6970

>T186894 WP_208165929.1 NZ_CP068228:c4143739-4142438 [Shewanella algae]
MSGAANLVLDMHLGDRIIGELSFDPATESFAVSYSQDWRQNGFPISPMIPLDGTGSSTQIAMFLGNLLPENRGLDYLIES
LGVSRGNTFALIRAIGLDTAGAVAFSPKGTELPQTAFREISDDEIILRLEEPELWPMEVWDGKPRLSVAGVQSKLNLFYN
GKQFGFGEGALSSTHILKFEKQRHLVINEFLTMRLAKSIAMNVANVEIRHFGQHKSLCVERFDRRYLPAEQRVLRRHIID
SCQALGFSVNKKYERNFGNGRDVRDIREGVSLPRLFALAEQCANPAAAKQDMLQWTLFNLLSGNADAHGKNYSFFMTPTG
MVPTPWYDLVCVALYEEFEQELAMAIDDEFDPDKIYAYQLAAFSEDIGLPRALVSNSLTRMATRISQEIEGVIAMLDGLD
KDEQAFVASYKAQLLARCECYLDIAPQINEMEL

Download         Length: 1302 bp

>T186894 NZ_CP089774:1543839-1544660 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8524.09 Da        Isoelectric Point: 9.0186

>AT186894 WP_025888014.1 NZ_CP068228:c4143978-4143742 [Shewanella algae]
MVSPLTPHSLGALIKVRRKEAALTLDVAAMLCGVTKKTFIRVEKGEDVYISTVFKILDGLGIHLLAQPKPDVDSTGWY

Download         Length: 237 bp

>AT186894 NZ_CP089774:1544653-1544889 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References