Detailed information of TA system TA186893

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4050177..4051726
• Replicon: chromosome
• Accession: NZ_CP068228
• Organism: Shewanella algae strain G1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JKK44_RS18125
• Protein ID: WP_071237208.1
• Coordinates: 4050425..4051726 (+)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JKK44_RS18120
• Protein ID: WP_025011264.1
• Coordinates: 4050177..4050425 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JKK44_RS18090 (JKK44_18085)	4045667..4046083	+	417	WP_208165907.1	hypothetical protein	-
JKK44_RS18095 (JKK44_18090)	4046080..4047012	+	933	WP_208165908.1	hypothetical protein	-
JKK44_RS18100 (JKK44_18095)	4047144..4047890	+	747	WP_208165909.1	hypothetical protein	-
JKK44_RS18105 (JKK44_18100)	4048527..4049030	+	504	WP_208149805.1	hypothetical protein	-
JKK44_RS18110 (JKK44_18105)	4049112..4049282	+	171	WP_208165910.1	hypothetical protein	-
JKK44_RS18115 (JKK44_18110)	4049279..4049869	-	591	WP_208165911.1	hypothetical protein	-
JKK44_RS18120 (JKK44_18115)	4050177..4050425	+	249	WP_025011264.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
JKK44_RS18125 (JKK44_18120)	4050425..4051726	+	1302	WP_071237208.1	type II toxin-antitoxin system HipA family toxin	Toxin
JKK44_RS18130 (JKK44_18125)	4051867..4053234	-	1368	WP_028781110.1	L-cystine transporter	-
JKK44_RS18135 (JKK44_18130)	4053538..4055565	+	2028	WP_071237209.1	S9 family peptidase	-
JKK44_RS18140 (JKK44_18135)	4055643..4056215	-	573	WP_071237210.1	LysE family translocator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-64)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 48719.63 Da
• Isoelectric Point: 9.6958

>T186893 WP_071237208.1 NZ_CP068228:4050425-4051726 [Shewanella algae]
MQKLIAYMNGELVGTLAKHKNGAHTFQYDKDWITNAMARPLSLSLRLQLPPITSDAVINYFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGKDSVGAIALFPPEHPYKKEPLSYEILDNKKLEAVLSAYKSDIPLGMLKEEEDFRISVAGAQEKTAL
LFIDGQWCIPKRNTPTTHIIKLPIGEIPQASATLDLKDSVENEYLCIELAKALGFAVPSVNIIKTDNLKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIEQIMKLLMGSSNALEDRYSFMRFQVFQWIIGATDGHAKNFSIYID
RGGSYRLTPFYDILSAYPLLGGKGLNIRQLKLAMGLKATKGKKYEINKILPRHFLDTAKAVNFSQDKMQRIMDEMKGALP
KAISQVRANLPEGFPEHISNSIFENAKKIIKKI

Nucleotide

• Length: 1302 bp

>T186893 NZ_CP089774:c1395775-1395482 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9366.70 Da
• Isoelectric Point: 6.2564

>AT186893 WP_025011264.1 NZ_CP068228:4050177-4050425 [Shewanella algae]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLVQAMDLTLSIQEKTQLTSPSENDDE
SW

Nucleotide

• Length: 249 bp

>AT186893 NZ_CP089774:c1396041-1395772 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA