Detailed information of TA system TA186892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 3737083..3738228
• Replicon: chromosome
• Accession: NZ_CP068228
• Organism: Shewanella algae strain G1

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JKK44_RS16830
• Protein ID: WP_054744620.1
• Coordinates: 3737083..3737829 (-)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JKK44_RS16835
• Protein ID: WP_071238536.1
• Coordinates: 3737866..3738228 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JKK44_RS16805 (JKK44_16800)	3732300..3732866	-	567	WP_025011535.1	phosphoribosyltransferase family protein	-
JKK44_RS16810 (JKK44_16805)	3733278..3734003	+	726	WP_044735676.1	basic amino acid ABC transporter substrate-binding protein	-
JKK44_RS16815 (JKK44_16810)	3734010..3734687	+	678	WP_025011537.1	amino acid ABC transporter permease	-
JKK44_RS16820 (JKK44_16815)	3734680..3735405	+	726	WP_071238534.1	amino acid ABC transporter ATP-binding protein	-
JKK44_RS16825 (JKK44_16820)	3735504..3737069	+	1566	WP_208165848.1	hypothetical protein	-
JKK44_RS16830 (JKK44_16825)	3737083..3737829	-	747	WP_054744620.1	RES family NAD+ phosphorylase	Toxin
JKK44_RS16835 (JKK44_16830)	3737866..3738228	-	363	WP_071238536.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
JKK44_RS16840 (JKK44_16835)	3738461..3739114	+	654	WP_071238537.1	oxygen-insensitive NAD(P)H nitroreductase	-
JKK44_RS16845 (JKK44_16840)	3739245..3739886	+	642	WP_028780153.1	DNA-J related domain-containing protein	-
JKK44_RS16850 (JKK44_16845)	3740027..3740764	+	738	WP_045283713.1	DsbA family protein	-
JKK44_RS16855 (JKK44_16850)	3740865..3743192	-	2328	WP_107006062.1	penicillin-binding protein 1B	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (55-205)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (10-65)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 28870.61 Da
• Isoelectric Point: 4.6112

>T186892 WP_054744620.1 NZ_CP068228:c3737829-3737083 [Shewanella algae]
MDFSALEPQDFFPRPYLGRGYRLVESQEEAATLSLVDDFDEQMLLESLLDEVKPPYRSGTEHLHYLLKTPFRYPPLRHGS
RFGSITMESFFYASESWQTCLAEVAYYRFVFMADMLEPYLEPLRSEHMLYSVDINARDCADLTLLQGQEVQQQLTHKSNY
TYTQAMGAWLLQQQAQMIRYTSARAEEGVNLALHDPLVLQSTEPQECEYWICQSSADKVAFSRRNSRSMPLTWFLKDFLQ
DGQLPRPA

Nucleotide

• Length: 747 bp

>T186892 NZ_CP089774:1391332-1391763 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13153.19 Da
• Isoelectric Point: 10.4675

>AT186892 WP_071238536.1 NZ_CP068228:c3738228-3737866 [Shewanella algae]
MNTLEKANAAEVLFKAFSNACSELQLTQVEASRIIGVNPSTLSRNSGKGFKPDSKQGELQLQLIRLYRSLYAIAGGEKAF
MRHWLNSPNKALNGTPKTLLQTVVGLVSVNQYLDAMRGKV

Nucleotide

• Length: 363 bp

>AT186892 NZ_CP089774:1391075-1391335 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA