Detailed information of TA system TA186888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 781177..782726
• Replicon: chromosome
• Accession: NZ_CP068227
• Organism: Shewanella algae strain A59

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JKK33_RS03605
• Protein ID: WP_208125505.1
• Coordinates: 781177..782478 (-)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JKK33_RS03610
• Protein ID: WP_025011264.1
• Coordinates: 782478..782726 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JKK33_RS03590 (JKK33_03590)	776676..777260	+	585	WP_117200305.1	LysE family translocator	-
JKK33_RS03595 (JKK33_03595)	777338..779365	-	2028	WP_071237209.1	S9 family peptidase	-
JKK33_RS03600 (JKK33_03600)	779669..781036	+	1368	WP_028781110.1	L-cystine transporter	-
JKK33_RS03605 (JKK33_03605)	781177..782478	-	1302	WP_208125505.1	type II toxin-antitoxin system HipA family toxin	Toxin
JKK33_RS03610 (JKK33_03610)	782478..782726	-	249	WP_025011264.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
JKK33_RS03615 (JKK33_03615)	783239..784930	+	1692	WP_208125506.1	ATP-binding cassette domain-containing protein	-
JKK33_RS03620 (JKK33_03620)	784943..785317	-	375	WP_208125507.1	PH domain-containing protein	-
JKK33_RS03625 (JKK33_03625)	785328..787253	-	1926	WP_107352408.1	U32 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-64)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 48575.35 Da
• Isoelectric Point: 9.4388

>T186888 WP_208125505.1 NZ_CP068227:c782478-781177 [Shewanella algae]
MQKLIAYMNGELVGTLAKHKNGAHTFQYDKDWITNAIARPLSLSLRLQLPTITSDAVINYFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGKDSVGAIALFPPEHPYKKEPLSYEILDNKKLEAVLSAYKSDIPLGMLKEEEDFRISVAGAQEKTAL
LFIDGQWCIPKGNTPTTHIIKLPIGEIPQANATLDLKDSVENEYLCIELAKALGFAVPSVNIIKTDNLKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIAQIMKLLMGSSNALEDQYNFMRFQVFQWIIGATDGHAKNFSIYID
RGGSYRLTPFYDILSAYPLLGGKGLNIRQLKLAMGLKATKGKKYEINKILPRHFLDTAKAVNFSQDKMQRIMDEMKGALP
EAISQVRANLPEGFPEHISNSIFENAKKIIKKI

Nucleotide

• Length: 1302 bp

>T186888 NZ_CP089774:1020364-1020798 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9366.70 Da
• Isoelectric Point: 6.2564

>AT186888 WP_025011264.1 NZ_CP068227:c782726-782478 [Shewanella algae]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLVQAMDLTLSIQEKTQLTSPSENDDE
SW

Nucleotide

• Length: 249 bp

>AT186888 NZ_CP089774:1020179-1020358 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG