Detailed information of TA system TA186886

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1163693..1164838
• Replicon: chromosome
• Accession: NZ_CP068226
• Organism: Shewanella algae strain A291

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JKK45_RS05095
• Protein ID: WP_054744620.1
• Coordinates: 1164092..1164838 (+)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7X5Z3H2
• Locus tag: JKK45_RS05090
• Protein ID: WP_025011540.1
• Coordinates: 1163693..1164055 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JKK45_RS05075 (JKK45_05075)	1161157..1161894	-	738	WP_044733833.1	DsbA family protein	-
JKK45_RS05080 (JKK45_05080)	1162035..1162676	-	642	WP_044735675.1	DNA-J related domain-containing protein	-
JKK45_RS05085 (JKK45_05085)	1162807..1163460	-	654	WP_025886967.1	oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB	-
JKK45_RS05090 (JKK45_05090)	1163693..1164055	+	363	WP_025011540.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
JKK45_RS05095 (JKK45_05095)	1164092..1164838	+	747	WP_054744620.1	RES family NAD+ phosphorylase	Toxin
JKK45_RS05100 (JKK45_05100)	1164852..1166417	-	1566	WP_208124274.1	hypothetical protein	-
JKK45_RS05105 (JKK45_05105)	1166516..1167241	-	726	WP_025886969.1	amino acid ABC transporter ATP-binding protein	-
JKK45_RS05110 (JKK45_05110)	1167234..1167911	-	678	WP_044733837.1	amino acid ABC transporter permease	-
JKK45_RS05115 (JKK45_05115)	1167918..1168643	-	726	WP_044735676.1	basic amino acid ABC transporter substrate-binding protein	-
JKK45_RS05120 (JKK45_05120)	1169055..1169621	+	567	WP_025011535.1	phosphoribosyltransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (55-205)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-118)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 28870.61 Da
• Isoelectric Point: 4.6112

>T186886 WP_054744620.1 NZ_CP068226:1164092-1164838 [Shewanella algae]
MDFSALEPQDFFPRPYLGRGYRLVESQEEAATLSLVDDFDEQMLLESLLDEVKPPYRSGTEHLHYLLKTPFRYPPLRHGS
RFGSITMESFFYASESWQTCLAEVAYYRFVFMADMLEPYLEPLRSEHMLYSVDINARDCADLTLLQGQEVQQQLTHKSNY
TYTQAMGAWLLQQQAQMIRYTSARAEEGVNLALHDPLVLQSTEPQECEYWICQSSADKVAFSRRNSRSMPLTWFLKDFLQ
DGQLPRPA

Nucleotide

• Length: 747 bp

>T186886 NZ_CP089774:c761235-760798 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13125.14 Da
• Isoelectric Point: 10.4675

>AT186886 WP_025011540.1 NZ_CP068226:1163693-1164055 [Shewanella algae]
MNTLEKANAAEVLFKAFSNACSELQLTQAEASRIIGVNPSTLSRNSGKGFKPDSKQGELQLQLIRLYRSLYAIAGGEKAF
MRHWLNSPNKALNGTPKTLLQTVVGLVSVNQYLDAMRGKV

Nucleotide

• Length: 363 bp

>AT186886 NZ_CP089774:c761486-761232 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Structures

Antitoxin

• AlphaFold DB: A0A7X5Z3H2