Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 845356..846899 Replicon chromosome
Accession NZ_CP068226
Organism Shewanella algae strain A291

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JKK45_RS03790 Protein ID WP_208124184.1
Coordinates 845356..846651 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JKK45_RS03795 Protein ID WP_025011264.1
Coordinates 846651..846899 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKK45_RS03775 (JKK45_03775) 840855..841439 + 585 WP_044733696.1 LysE family translocator -
JKK45_RS03780 (JKK45_03780) 841517..843544 - 2028 WP_093982364.1 S9 family peptidase -
JKK45_RS03785 (JKK45_03785) 843848..845215 + 1368 WP_208124183.1 L-cystine transporter -
JKK45_RS03790 (JKK45_03790) 845356..846651 - 1296 WP_208124184.1 type II toxin-antitoxin system HipA family toxin Toxin
JKK45_RS03795 (JKK45_03795) 846651..846899 - 249 WP_025011264.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JKK45_RS03800 (JKK45_03800) 847413..849104 + 1692 WP_208124185.1 ATP-binding cassette domain-containing protein -
JKK45_RS03805 (JKK45_03805) 849116..849490 - 375 WP_093982368.1 PH domain-containing protein -
JKK45_RS03810 (JKK45_03810) 849501..851426 - 1926 WP_144128793.1 U32 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-399)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 48431.14 Da        Isoelectric Point: 9.4431

>T186885 WP_208124184.1 NZ_CP068226:c846651-845356 [Shewanella algae]
MQKLIAYMNGELVGTLAKHKNGAHTFQYDKDWITNAMARPLSLSLRLQLPTITSDAVINYFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGKDSVGAIALFPPEHPYKKEPLSYEILDNKKLEAVLSAYKSDIPLGMLKEEEDFRISVAGAQEKTAL
LFIDGQWCIPKGNTPTTHIIKLPIGEIPQASATLDLKDSVENEYLCIELAKALGFAVPSVNIIKTDNLKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIEQIMKLLMGSSNALEDRYNFMRFQVFQWIIGATDGHAKNFSIYIN
KGGSYRLTPFYDILSAYPLLGGLNIRQLKLAMGLKATKGKKYEINRILPRHFLDTAKAVNFSQDKMQRIMDEMKGALPEA
ISQVRANLPEGFPENISNSIFENAKKTIKKI

Download         Length: 1296 bp

>T186885 NZ_CP089774:c761235-760798 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9366.70 Da        Isoelectric Point: 6.2564

>AT186885 WP_025011264.1 NZ_CP068226:c846899-846651 [Shewanella algae]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLVQAMDLTLSIQEKTQLTSPSENDDE
SW

Download         Length: 249 bp

>AT186885 NZ_CP089774:c760688-760443 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References