186884

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1223896..1224357 Replicon chromosome
Accession NZ_CP068219
Organism Staphylococcus pasteuri strain FDAARGOS_1151

Toxin (Protein)


Gene name TsaT Uniprot ID A0A653ZJR3
Locus tag I6J08_RS06085 Protein ID WP_029055618.1
Coordinates 1224172..1224357 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A653ZJ41
Locus tag I6J08_RS13025 Protein ID WP_072291797.1
Coordinates 1223896..1224153 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J08_RS06045 (I6J08_06040) 1219103..1219426 + 324 WP_017637481.1 thioredoxin family protein -
I6J08_RS06050 (I6J08_06045) 1219535..1220074 - 540 WP_017637482.1 nitroreductase -
I6J08_RS06055 (I6J08_06050) 1220154..1220870 - 717 WP_017637483.1 type I 3-dehydroquinate dehydratase -
I6J08_RS06060 (I6J08_06055) 1221054..1221476 + 423 WP_017637484.1 organic hydroperoxide resistance protein -
I6J08_RS06065 (I6J08_06060) 1221760..1222251 + 492 WP_017637485.1 GNAT family N-acetyltransferase -
I6J08_RS06070 (I6J08_06065) 1222410..1222997 - 588 WP_017637486.1 histidine phosphatase family protein -
I6J08_RS06075 (I6J08_06070) 1223169..1223393 + 225 WP_017637487.1 hypothetical protein -
I6J08_RS06080 (I6J08_06075) 1223394..1223597 - 204 WP_029055617.1 sterile alpha motif-like domain-containing protein -
I6J08_RS13025 1223896..1224153 + 258 WP_072291797.1 hypothetical protein Antitoxin
I6J08_RS06085 (I6J08_06080) 1224172..1224357 + 186 WP_029055618.1 hypothetical protein Toxin
I6J08_RS06090 (I6J08_06085) 1224490..1225035 + 546 WP_051009457.1 lipoprotein N-acylation protein LnsA -
I6J08_RS06095 (I6J08_06090) 1225095..1225328 - 234 WP_017637826.1 hypothetical protein -
I6J08_RS06100 (I6J08_06095) 1225563..1226312 + 750 WP_017637827.1 poly-gamma-glutamate hydrolase family protein -
I6J08_RS06105 (I6J08_06100) 1226401..1226685 + 285 WP_017637828.1 hypothetical protein -
I6J08_RS06110 (I6J08_06105) 1226762..1226977 + 216 WP_017637829.1 hypothetical protein -
I6J08_RS06115 (I6J08_06110) 1227461..1227694 + 234 WP_017637830.1 hypothetical protein -
I6J08_RS06120 (I6J08_06115) 1227916..1228149 + 234 WP_017637831.1 hypothetical protein -
I6J08_RS06125 (I6J08_06120) 1228368..1228568 - 201 WP_002450876.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-99)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7023.71 Da        Isoelectric Point: 10.1605

>T186884 WP_029055618.1 NZ_CP068219:1224172-1224357 [Staphylococcus pasteuri]
MSLHFTILFWLSIIFLIAGTIVLVTMLKTKKESKKESYLGFTIVFFIFGLAMLIYTLIFGL

Download         Length: 186 bp

>T186884 NZ_CP089774:c760456-760148 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9929.12 Da        Isoelectric Point: 4.1911

>AT186884 WP_072291797.1 NZ_CP068219:1223896-1224153 [Staphylococcus pasteuri]
MKLYFLHVINILLTILFVIFNIVITNNTNLDDTLWLVPGLIVCGLIIIISLFIAISNKDLLSEILFFINIILTLYYIYPI
FYDFL

Download         Length: 258 bp

>AT186884 NZ_CP089774:c760688-760443 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A653ZJR3

Antitoxin

Source ID Structure
AlphaFold DB A0A653ZJ41

References