Detailed information of TA system TA186880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 236189..236992
• Replicon: chromosome
• Accession: NZ_CP068219
• Organism: Staphylococcus pasteuri strain FDAARGOS_1151

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: I6J08_RS01325
• Protein ID: WP_017638030.1
• Coordinates: 236816..236992 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A654BAN2
• Locus tag: I6J08_RS01320
• Protein ID: WP_017638029.1
• Coordinates: 236189..236788 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J08_RS01300 (I6J08_01300)	232088..233548	+	1461	WP_017638025.1	ABC transporter substrate-binding protein/permease	-
I6J08_RS01305 (I6J08_01305)	233541..234263	+	723	WP_017638026.1	amino acid ABC transporter ATP-binding protein	-
I6J08_RS01310 (I6J08_01310)	234406..235536	+	1131	WP_017638027.1	tRNA epoxyqueuosine(34) reductase QueG	-
I6J08_RS01315 (I6J08_01315)	235537..236007	+	471	WP_017638028.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
I6J08_RS01320 (I6J08_01320)	236189..236788	+	600	WP_017638029.1	glucosamine-6-phosphate isomerase	Antitoxin
I6J08_RS01325 (I6J08_01325)	236816..236992	+	177	WP_017638030.1	SAS053 family protein	Toxin
I6J08_RS01330 (I6J08_01330)	237144..237536	+	393	WP_017638031.1	hypothetical protein	-
I6J08_RS01335 (I6J08_01335)	237692..239077	+	1386	WP_046466851.1	class II fumarate hydratase	-
I6J08_RS01340 (I6J08_01340)	239137..239967	-	831	WP_017638033.1	RluA family pseudouridine synthase	-
I6J08_RS01345 (I6J08_01345)	240145..241257	+	1113	WP_017638034.1	GAF domain-containing sensor histidine kinase	-
I6J08_RS01350 (I6J08_01350)	241278..241901	+	624	WP_017638035.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6787.12 Da
• Isoelectric Point: 3.8537

>T186880 WP_017638030.1 NZ_CP068219:236816-236992 [Staphylococcus pasteuri]
MTQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEDKLNQSHDSDVRSDLEE

Nucleotide

• Length: 177 bp

>T186880 NZ_CP068219:236816-236992 [Staphylococcus pasteuri]
ATGACACAAAATAAAGATTCTAAAACTAATTATCATGAAGAAGAAAATGCTATGGTAACTGATTTAGATGATTTAAAAGA
TTTAGGTAAAGAAATGGAACAAATTTCTGAGGAAAATGATGAAGATAAATTAAACCAATCACATGATTCAGATGTTCGTT
CTGATTTAGAAGAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22646.58 Da
• Isoelectric Point: 4.9933

>AT186880 WP_017638029.1 NZ_CP068219:236189-236788 [Staphylococcus pasteuri]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVELHAVDFSQINILDYDENKSYYEALGV
PQSQIYSLSYNQDANEFISDKIKTKENKGKLVLQVVSIDENGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT186880 NZ_CP068219:236189-236788 [Staphylococcus pasteuri]
ATGGCAATGAACTTTAAAGTATTCGAAGATAAACAAAGAGTAGCTGAATATACAGCAGACATTTTGAGAAAACAGTTTAA
CAACAATCCTATGACTATCGCTGGTGTTCACTTAACTAAAGACCATGCACCTGTATTAGATGAACTTAAAAAGAACGTTG
AGTTACATGCAGTTGATTTTAGTCAAATTAACATTTTAGATTATGATGAAAATAAATCATACTATGAAGCTTTAGGCGTA
CCTCAAAGCCAAATTTATTCATTATCTTATAATCAAGATGCTAATGAATTTATTTCTGATAAAATTAAAACAAAAGAAAA
TAAAGGTAAATTAGTGTTACAAGTAGTTTCTATTGATGAGAATGGCAACCTTGATGTAAGCGTAAGACAAGGATTATTAG
AAGCGCGTGAAATTTTCTTAGTTGTTACTGGTAGCAATAAACGCGAAGTAGTTGAAAAATTATATAATGAAAATGGTAAG
TCTAATTATGAACCAGCAGATTTAAAAGCTCATCGCATGGTTAACGTTATTTTAGATAAAGAAGCAGCGGCTGGATTACC
TGAAGATGTTAAAGAATACTTCACTGCTCGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A654BAN2