Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 98955..99484 Replicon chromosome
Accession NZ_CP068219
Organism Staphylococcus pasteuri strain FDAARGOS_1151

Toxin (Protein)


Gene name mazF Uniprot ID A0A654BHV4
Locus tag I6J08_RS00535 Protein ID WP_017637331.1
Coordinates 99122..99484 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A654BG87
Locus tag I6J08_RS00530 Protein ID WP_017637332.1
Coordinates 98955..99125 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J08_RS00505 (I6J08_00505) 94772..95245 + 474 WP_029056193.1 PH domain-containing protein -
I6J08_RS00510 (I6J08_00510) 95238..96770 + 1533 WP_119477691.1 PH domain-containing protein -
I6J08_RS00515 (I6J08_00515) 96757..97251 + 495 WP_046466913.1 PH domain-containing protein -
I6J08_RS00520 (I6J08_00520) 97289..97666 + 378 WP_017637334.1 holo-ACP synthase -
I6J08_RS00525 (I6J08_00525) 97715..98863 + 1149 WP_208970182.1 alanine racemase -
I6J08_RS00530 (I6J08_00530) 98955..99125 + 171 WP_017637332.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
I6J08_RS00535 (I6J08_00535) 99122..99484 + 363 WP_017637331.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6J08_RS00540 (I6J08_00540) 99808..100809 + 1002 WP_017637330.1 PP2C family protein-serine/threonine phosphatase -
I6J08_RS00545 (I6J08_00545) 100904..101230 + 327 WP_029056199.1 anti-sigma factor antagonist -
I6J08_RS00550 (I6J08_00550) 101232..101711 + 480 WP_208970181.1 anti-sigma B factor RsbW -
I6J08_RS00555 (I6J08_00555) 101686..102456 + 771 WP_017637327.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13586.75 Da        Isoelectric Point: 9.9783

>T186879 WP_017637331.1 NZ_CP068219:99122-99484 [Staphylococcus pasteuri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSENKMKEVDYALDISLGLHNFNHPKT

Download         Length: 363 bp

>T186879 NZ_CP089774:708416-708817 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6313.93 Da        Isoelectric Point: 3.8309

>AT186879 WP_017637332.1 NZ_CP068219:98955-99125 [Staphylococcus pasteuri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLNSNAKNE

Download         Length: 171 bp

>AT186879 NZ_CP089774:708174-708419 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A654BHV4

Antitoxin

Source ID Structure
AlphaFold DB A0A654BG87

References