Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 87808..88318 Replicon chromosome
Accession NZ_CP068219
Organism Staphylococcus pasteuri strain FDAARGOS_1151

Toxin (Protein)


Gene name TsdT Uniprot ID A0A654BJR5
Locus tag I6J08_RS00475 Protein ID WP_017636752.1
Coordinates 88112..88318 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A654BGA3
Locus tag I6J08_RS00470 Protein ID WP_017636753.1
Coordinates 87808..88101 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J08_RS00445 (I6J08_00445) 82961..83752 + 792 WP_017636758.1 hydroxyethylthiazole kinase -
I6J08_RS00450 (I6J08_00450) 83753..84394 + 642 WP_017636757.1 thiamine phosphate synthase -
I6J08_RS00455 (I6J08_00455) 84483..85352 + 870 WP_017636756.1 membrane protein insertase YidC -
I6J08_RS00460 (I6J08_00460) 85391..86035 - 645 WP_017636755.1 HD domain-containing protein -
I6J08_RS00465 (I6J08_00465) 86135..87619 - 1485 WP_017636754.1 cardiolipin synthase -
I6J08_RS00470 (I6J08_00470) 87808..88101 + 294 WP_017636753.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6J08_RS00475 (I6J08_00475) 88112..88318 + 207 WP_017636752.1 heavy metal-associated domain-containing protein Toxin
I6J08_RS00480 (I6J08_00480) 88456..88593 + 138 WP_017636751.1 Lmo0850 family protein -
I6J08_RS00485 (I6J08_00485) 88727..89917 - 1191 WP_017636750.1 FtsW/RodA/SpoVE family cell cycle protein -
I6J08_RS00490 (I6J08_00490) 90289..91359 + 1071 WP_017636749.1 D-alanine--D-alanine ligase -
I6J08_RS00495 (I6J08_00495) 91375..92736 + 1362 WP_017636748.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(17-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7656.65 Da        Isoelectric Point: 4.4368

>T186878 WP_017636752.1 NZ_CP068219:88112-88318 [Staphylococcus pasteuri]
VQQKIVYTSGIKTTEQANKMETILKEMIGVYDANVDLSNGHISVEFETPANLNSIEKEIYDSGFKVLY

Download         Length: 207 bp

>T186878 NZ_CP089774:c702497-702084 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.74 Da        Isoelectric Point: 6.3270

>AT186878 WP_017636753.1 NZ_CP068219:87808-88101 [Staphylococcus pasteuri]
VTEQDHAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCITEKVNNGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT186878 NZ_CP089774:c702730-702494 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A654BJR5

Antitoxin

Source ID Structure
AlphaFold DB A0A654BGA3

References