186877

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2172606..2173067 Replicon chromosome
Accession NZ_CP068216
Organism Staphylococcus pasteuri strain FDAARGOS_1152

Toxin (Protein)


Gene name TsaT Uniprot ID A0A653ZJR3
Locus tag I6J09_RS10520 Protein ID WP_029055618.1
Coordinates 2172606..2172791 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A653ZJ41
Locus tag I6J09_RS12560 Protein ID WP_072291797.1
Coordinates 2172810..2173067 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J09_RS10480 (I6J09_10475) 2168391..2168591 + 201 WP_002450876.1 cold-shock protein -
I6J09_RS10485 (I6J09_10480) 2168810..2169043 - 234 WP_154894907.1 hypothetical protein -
I6J09_RS10490 (I6J09_10485) 2169265..2169498 - 234 WP_017637830.1 hypothetical protein -
I6J09_RS10495 (I6J09_10490) 2169981..2170196 - 216 WP_017637829.1 hypothetical protein -
I6J09_RS10500 (I6J09_10495) 2170273..2170557 - 285 WP_029056556.1 hypothetical protein -
I6J09_RS10505 (I6J09_10500) 2170646..2171395 - 750 WP_117239109.1 poly-gamma-glutamate hydrolase family protein -
I6J09_RS10510 (I6J09_10505) 2171635..2171868 + 234 WP_017637826.1 hypothetical protein -
I6J09_RS10515 (I6J09_10510) 2171928..2172464 - 537 WP_225307031.1 lipoprotein N-acylation protein LnsA -
I6J09_RS10520 (I6J09_10515) 2172606..2172791 - 186 WP_029055618.1 hypothetical protein Toxin
I6J09_RS12560 2172810..2173067 - 258 WP_072291797.1 hypothetical protein Antitoxin
I6J09_RS10525 (I6J09_10520) 2173366..2173569 + 204 WP_029055617.1 sterile alpha motif-like domain-containing protein -
I6J09_RS10530 (I6J09_10525) 2173570..2173794 - 225 WP_017637487.1 hypothetical protein -
I6J09_RS10535 (I6J09_10530) 2173966..2174553 + 588 WP_017637486.1 histidine phosphatase family protein -
I6J09_RS10540 (I6J09_10535) 2174713..2175204 - 492 WP_017637485.1 GNAT family N-acetyltransferase -
I6J09_RS10545 (I6J09_10540) 2175488..2175910 - 423 WP_208969835.1 organic hydroperoxide resistance protein -
I6J09_RS10550 (I6J09_10545) 2176094..2176810 + 717 WP_154894905.1 type I 3-dehydroquinate dehydratase -
I6J09_RS10555 (I6J09_10550) 2176889..2177428 + 540 WP_017637482.1 nitroreductase -
I6J09_RS10560 (I6J09_10555) 2177537..2177860 - 324 WP_017637481.1 thioredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7023.71 Da        Isoelectric Point: 10.1605

>T186877 WP_029055618.1 NZ_CP068216:c2172791-2172606 [Staphylococcus pasteuri]
MSLHFTILFWLSIIFLIAGTIVLVTMLKTKKESKKESYLGFTIVFFIFGLAMLIYTLIFGL

Download         Length: 186 bp

>T186877 NZ_CP089774:c700161-699769 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9929.12 Da        Isoelectric Point: 4.1911

>AT186877 WP_072291797.1 NZ_CP068216:c2173067-2172810 [Staphylococcus pasteuri]
MKLYFLHVINILLTILFVIFNIVITNNTNLDDTLWLVPGLIVCGLIIIISLFIAISNKDLLSEILFFINIILTLYYIYPI
FYDFL

Download         Length: 258 bp

>AT186877 NZ_CP089774:c700415-700158 [Mycobacterium tuberculosis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A653ZJR3

Antitoxin

Source ID Structure
AlphaFold DB A0A653ZJ41

References