Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 815053..815563 Replicon chromosome
Accession NZ_CP068216
Organism Staphylococcus pasteuri strain FDAARGOS_1152

Toxin (Protein)


Gene name TsdT Uniprot ID A0A654BJR5
Locus tag I6J09_RS03910 Protein ID WP_017636752.1
Coordinates 815053..815259 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A654BGA3
Locus tag I6J09_RS03915 Protein ID WP_017636753.1
Coordinates 815270..815563 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J09_RS03890 (I6J09_03885) 810635..811996 - 1362 WP_017636748.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
I6J09_RS03895 (I6J09_03890) 812012..813082 - 1071 WP_029056190.1 D-alanine--D-alanine ligase -
I6J09_RS03900 (I6J09_03895) 813454..814644 + 1191 WP_208970005.1 FtsW/RodA/SpoVE family cell cycle protein -
I6J09_RS03905 (I6J09_03900) 814778..814915 - 138 WP_017636751.1 Lmo0850 family protein -
I6J09_RS03910 (I6J09_03905) 815053..815259 - 207 WP_017636752.1 heavy metal-associated domain-containing protein Toxin
I6J09_RS03915 (I6J09_03910) 815270..815563 - 294 WP_017636753.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6J09_RS03920 (I6J09_03915) 815752..817236 + 1485 WP_208970006.1 cardiolipin synthase -
I6J09_RS03925 (I6J09_03920) 817336..817980 + 645 WP_017636755.1 HD domain-containing protein -
I6J09_RS03930 (I6J09_03925) 818019..818888 - 870 WP_017636756.1 membrane protein insertase YidC -
I6J09_RS03935 (I6J09_03930) 818977..819618 - 642 WP_046466906.1 thiamine phosphate synthase -
I6J09_RS03940 (I6J09_03935) 819619..820410 - 792 WP_208970007.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(17-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7656.65 Da        Isoelectric Point: 4.4368

>T186876 WP_017636752.1 NZ_CP068216:c815259-815053 [Staphylococcus pasteuri]
VQQKIVYTSGIKTTEQANKMETILKEMIGVYDANVDLSNGHISVEFETPANLNSIEKEIYDSGFKVLY

Download         Length: 207 bp

>T186876 NZ_CP089774:682852-683259 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.74 Da        Isoelectric Point: 6.3270

>AT186876 WP_017636753.1 NZ_CP068216:c815563-815270 [Staphylococcus pasteuri]
VTEQDHAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCITEKVNNGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT186876 NZ_CP089774:682640-682855 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A654BJR5

Antitoxin

Source ID Structure
AlphaFold DB A0A654BGA3

References