Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 803887..804416 Replicon chromosome
Accession NZ_CP068216
Organism Staphylococcus pasteuri strain FDAARGOS_1152

Toxin (Protein)


Gene name mazF Uniprot ID A0A654BHV4
Locus tag I6J09_RS03850 Protein ID WP_017637331.1
Coordinates 803887..804249 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag I6J09_RS03855 Protein ID WP_002451626.1
Coordinates 804246..804416 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J09_RS03830 (I6J09_03825) 800915..801685 - 771 WP_029056200.1 RNA polymerase sigma factor SigB -
I6J09_RS03835 (I6J09_03830) 801660..802139 - 480 WP_017637328.1 anti-sigma B factor RsbW -
I6J09_RS03840 (I6J09_03835) 802141..802467 - 327 WP_029056199.1 anti-sigma factor antagonist -
I6J09_RS03845 (I6J09_03840) 802562..803563 - 1002 WP_017637330.1 PP2C family protein-serine/threonine phosphatase -
I6J09_RS03850 (I6J09_03845) 803887..804249 - 363 WP_017637331.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6J09_RS03855 (I6J09_03850) 804246..804416 - 171 WP_002451626.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
I6J09_RS03860 (I6J09_03855) 804508..805656 - 1149 WP_119622766.1 alanine racemase -
I6J09_RS03865 (I6J09_03860) 805705..806082 - 378 WP_046466914.1 holo-ACP synthase -
I6J09_RS03870 (I6J09_03865) 806120..806614 - 495 WP_208970004.1 PH domain-containing protein -
I6J09_RS03875 (I6J09_03870) 806601..808133 - 1533 WP_154895591.1 PH domain-containing protein -
I6J09_RS03880 (I6J09_03875) 808126..808599 - 474 WP_029056193.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13586.75 Da        Isoelectric Point: 9.9783

>T186875 WP_017637331.1 NZ_CP068216:c804249-803887 [Staphylococcus pasteuri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSENKMKEVDYALDISLGLHNFNHPKT

Download         Length: 363 bp

>T186875 NZ_CP089774:c645566-645153 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT186875 WP_002451626.1 NZ_CP068216:c804416-804246 [Staphylococcus pasteuri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp

>AT186875 NZ_CP089774:c645829-645563 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A654BHV4

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References