Detailed information of TA system TA186872

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4167967..4168574
• Replicon: chromosome
• Accession: NZ_CP068215
• Organism: Enterobacter hormaechei strain FDAARGOS_1078

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2J0PXG2
• Locus tag: I6I35_RS20100
• Protein ID: WP_071788668.1
• Coordinates: 4168389..4168574 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A8H9RQ79
• Locus tag: I6I35_RS20095
• Protein ID: WP_032651934.1
• Coordinates: 4167967..4168374 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I35_RS20065	4163808..4164461	+	654	WP_023295601.1	3-keto-L-gulonate-6-phosphate decarboxylase UlaD	-
I6I35_RS20070	4164464..4165324	+	861	WP_017693794.1	L-ribulose-5-phosphate 3-epimerase	-
I6I35_RS20075	4165318..4166013	+	696	WP_017382588.1	L-ribulose-5-phosphate 4-epimerase	-
I6I35_RS20080	4166014..4166301	-	288	Protein_3931	helix-turn-helix domain-containing protein	-
I6I35_RS20085	4166308..4166685	+	378	Protein_3932	glycoside hydrolase family 127 protein	-
I6I35_RS20090	4166887..4167963	+	1077	WP_032651932.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
I6I35_RS20095	4167967..4168374	-	408	WP_032651934.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6I35_RS20100	4168389..4168574	-	186	WP_071788668.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6I35_RS20105	4168824..4170362	-	1539	WP_032651936.1	aldehyde dehydrogenase AldB	-
I6I35_RS20110	4170529..4171413	+	885	WP_032651938.1	ROK family protein	-
I6I35_RS20115	4171417..4173255	-	1839	WP_032651940.1	selenocysteine-specific translation elongation factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6822.05 Da
• Isoelectric Point: 11.5191

>T186872 WP_071788668.1 NZ_CP068215:c4168574-4168389 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T186872 NZ_CP089774:367092-367394 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15110.90 Da
• Isoelectric Point: 4.3197

>AT186872 WP_032651934.1 NZ_CP068215:c4168374-4167967 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPR

Nucleotide

• Length: 408 bp

>AT186872 NZ_CP089774:367442-367663 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Structures

Toxin

• AlphaFold DB: A0A2J0PXG2