Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3575784..3576463 Replicon chromosome
Accession NZ_CP068215
Organism Enterobacter hormaechei strain FDAARGOS_1078

Toxin (Protein)


Gene name ykfI Uniprot ID A0A8H9RR71
Locus tag I6I35_RS17210 Protein ID WP_032655083.1
Coordinates 3575784..3576125 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8H9RPW5
Locus tag I6I35_RS17215 Protein ID WP_001548170.1
Coordinates 3576146..3576463 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I35_RS17190 3571071..3572816 + 1746 WP_003862574.1 DNA primase -
I6I35_RS17195 3572969..3574813 + 1845 WP_015571912.1 RNA polymerase sigma factor RpoD -
I6I35_RS17200 3574916..3575422 - 507 WP_017384024.1 G/U mismatch-specific DNA glycosylase -
I6I35_RS17210 3575784..3576125 - 342 WP_032655083.1 TA system toxin CbtA family protein Toxin
I6I35_RS17215 3576146..3576463 - 318 WP_001548170.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6I35_RS17220 3576483..3576704 - 222 WP_032655087.1 DUF987 domain-containing protein -
I6I35_RS17225 3576713..3577189 - 477 WP_032655090.1 RadC family protein -
I6I35_RS17230 3577205..3577663 - 459 WP_032655093.1 antirestriction protein -
I6I35_RS17235 3577765..3578004 - 240 WP_001115184.1 DUF905 domain-containing protein -
I6I35_RS17240 3578095..3579855 - 1761 Protein_3377 autotransporter domain-containing protein -
I6I35_RS17245 3580169..3580996 - 828 WP_000197390.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13031.15 Da        Isoelectric Point: 10.4476

>T186871 WP_032655083.1 NZ_CP068215:c3576125-3575784 [Enterobacter hormaechei]
MKTLPATTQRAAKPCLSPVAVWQMLLTRLLKQHYGLTLNDTPFSEERVIQEHIDAGITLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAVDILRARQATGLLRQSRKNLVR

Download         Length: 342 bp

>T186871 NZ_CP089774:367092-367394 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11883.46 Da        Isoelectric Point: 7.0810

>AT186871 WP_001548170.1 NZ_CP068215:c3576463-3576146 [Enterobacter hormaechei]
MTHINWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDTECRKLDETCPHFIRHMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQS

Download         Length: 318 bp

>AT186871 NZ_CP089774:366868-367095 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References