Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3363821..3364478 Replicon chromosome
Accession NZ_CP068215
Organism Enterobacter hormaechei strain FDAARGOS_1078

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T9SH06
Locus tag I6I35_RS16200 Protein ID WP_023295382.1
Coordinates 3363821..3364231 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag I6I35_RS16205 Protein ID WP_003863437.1
Coordinates 3364212..3364478 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I35_RS16180 3359819..3361552 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
I6I35_RS16185 3361558..3362271 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6I35_RS16190 3362300..3363196 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
I6I35_RS16195 3363298..3363819 + 522 WP_015571793.1 flavodoxin FldB -
I6I35_RS16200 3363821..3364231 - 411 WP_023295382.1 protein YgfX Toxin
I6I35_RS16205 3364212..3364478 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
I6I35_RS16210 3364773..3365753 + 981 WP_017382888.1 tRNA-modifying protein YgfZ -
I6I35_RS16215 3365865..3366524 - 660 WP_003863433.1 hemolysin III family protein -
I6I35_RS16220 3366791..3367522 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
I6I35_RS16225 3367639..3369072 + 1434 WP_023295383.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16291.18 Da        Isoelectric Point: 11.4775

>T186870 WP_023295382.1 NZ_CP068215:c3364231-3363821 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGAPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T186870 NZ_CP089774:72292-72693 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT186870 WP_003863437.1 NZ_CP068215:c3364478-3364212 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT186870 NZ_CP089774:72060-72299 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9SH06

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References