Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1782746..1783485 Replicon chromosome
Accession NZ_CP068215
Organism Enterobacter hormaechei strain FDAARGOS_1078

Toxin (Protein)


Gene name tacT Uniprot ID A0A7T9PDC6
Locus tag I6I35_RS08680 Protein ID WP_032653599.1
Coordinates 1782746..1783231 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag I6I35_RS08685 Protein ID WP_003857131.1
Coordinates 1783219..1783485 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I35_RS08650 1778244..1778858 + 615 WP_080337332.1 NUDIX hydrolase -
I6I35_RS08655 1779042..1779677 - 636 WP_015570517.1 DUF421 domain-containing protein -
I6I35_RS08660 1779687..1780133 - 447 WP_032653595.1 DUF3290 domain-containing protein -
I6I35_RS08665 1780562..1780890 - 329 Protein_1697 helix-turn-helix domain-containing protein -
I6I35_RS08670 1781145..1782110 + 966 WP_032648329.1 hypothetical protein -
I6I35_RS08675 1782126..1782695 + 570 WP_032648331.1 hypothetical protein -
I6I35_RS08680 1782746..1783231 - 486 WP_032653599.1 GNAT family N-acetyltransferase Toxin
I6I35_RS08685 1783219..1783485 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
I6I35_RS08690 1783549..1784478 - 930 WP_032653603.1 LysR family transcriptional regulator -
I6I35_RS08695 1784608..1785996 + 1389 WP_032653606.1 MFS transporter -
I6I35_RS08700 1786019..1787014 - 996 WP_017382342.1 DUF2891 domain-containing protein -
I6I35_RS08705 1787024..1788010 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17539.29 Da        Isoelectric Point: 10.3883

>T186860 WP_032653599.1 NZ_CP068215:c1783231-1782746 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGKAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T186860 NZ_CP089773:c3112110-3111754 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT186860 WP_003857131.1 NZ_CP068215:c1783485-1783219 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT186860 NZ_CP089773:c3112324-3112094 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9PDC6

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References