Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 531487..532107 Replicon chromosome
Accession NZ_CP068215
Organism Enterobacter hormaechei strain FDAARGOS_1078

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag I6I35_RS02505 Protein ID WP_015571250.1
Coordinates 531487..531705 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag I6I35_RS02510 Protein ID WP_006809850.1
Coordinates 531733..532107 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I35_RS02475 527499..527759 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
I6I35_RS02480 527762..527902 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
I6I35_RS02485 527899..528609 - 711 WP_032652732.1 GNAT family N-acetyltransferase -
I6I35_RS02490 528711..530171 + 1461 WP_032652734.1 PLP-dependent aminotransferase family protein -
I6I35_RS02495 530143..530610 - 468 WP_023296041.1 hypothetical protein -
I6I35_RS02500 530727..531278 - 552 WP_015571251.1 maltose O-acetyltransferase -
I6I35_RS02505 531487..531705 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
I6I35_RS02510 531733..532107 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
I6I35_RS02515 532618..535764 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
I6I35_RS02520 535787..536980 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T186857 WP_015571250.1 NZ_CP068215:c531705-531487 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T186857 NZ_CP089773:c2978339-2978016 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT186857 WP_006809850.1 NZ_CP068215:c532107-531733 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT186857 NZ_CP089773:c2978664-2978419 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References