Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 5100329..5100801 Replicon chromosome
Accession NZ_CP068214
Organism Serratia ureilytica strain FDAARGOS_1089

Toxin (Protein)


Gene name relE Uniprot ID A0A8B4GM79
Locus tag I6I46_RS24355 Protein ID WP_033645001.1
Coordinates 5100526..5100801 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I6I46_RS24350 Protein ID WP_033645226.1
Coordinates 5100329..5100526 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I46_RS24320 5095519..5096787 + 1269 WP_069100566.1 glycerol-3-phosphate dehydrogenase subunit GlpB -
I6I46_RS24325 5096784..5097983 + 1200 WP_038874129.1 anaerobic glycerol-3-phosphate dehydrogenase subunit C -
I6I46_RS24330 5098018..5098581 - 564 WP_201911028.1 DcrB family lipoprotein -
I6I46_RS24335 5098662..5099096 - 435 WP_060660071.1 GNAT family N-acetyltransferase -
I6I46_RS24340 5099138..5099797 - 660 WP_033652423.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -
I6I46_RS24345 5100019..5100264 + 246 WP_025304890.1 sulfurtransferase TusA -
I6I46_RS24350 5100329..5100526 + 198 WP_033645226.1 hypothetical protein Antitoxin
I6I46_RS24355 5100526..5100801 + 276 WP_033645001.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
I6I46_RS24360 5100861..5103173 - 2313 WP_201911030.1 zinc/cadmium/mercury/lead-transporting ATPase -
I6I46_RS24365 5103855..5105318 + 1464 WP_033644999.1 serralysin family metalloprotease -
I6I46_RS24370 5105373..5105750 + 378 WP_025304893.1 AprI/Inh family metalloprotease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10682.57 Da        Isoelectric Point: 11.2806

>T186855 WP_033645001.1 NZ_CP068214:5100526-5100801 [Serratia ureilytica]
MLNIEWTRAARQDLAEIVGFIANDNPLAARKMKVLIMEAVTPAARHPRIFRRGRVDGTHEIPLHPHYLLIYQVLETHIRV
LRVLHTRRQYP

Download         Length: 276 bp

>T186855 NZ_CP089773:c2872912-2872517 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7395.40 Da        Isoelectric Point: 4.1359

>AT186855 WP_033645226.1 NZ_CP068214:5100329-5100526 [Serratia ureilytica]
MSILLLPTVAKMENEEHTQGYERWFLERVQEAMDEPWPGIPHDDVMAEMDAVIAAAEARINAKQA

Download         Length: 198 bp

>AT186855 NZ_CP089773:c2873154-2872909 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GM79

Antitoxin

Source ID Structure

References