Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4932181..4932782 Replicon chromosome
Accession NZ_CP068214
Organism Serratia ureilytica strain FDAARGOS_1089

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag I6I46_RS23595 Protein ID WP_025304766.1
Coordinates 4932181..4932561 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag I6I46_RS23600 Protein ID WP_025304767.1
Coordinates 4932561..4932782 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I46_RS23570 4927428..4928708 + 1281 WP_033652318.1 DUF3748 domain-containing protein -
I6I46_RS23575 4928739..4929086 - 348 WP_016929593.1 YceK/YidQ family lipoprotein -
I6I46_RS23580 4929396..4929809 + 414 WP_004933919.1 heat shock chaperone IbpA -
I6I46_RS23585 4929916..4930344 + 429 WP_004933922.1 heat shock chaperone IbpB -
I6I46_RS23590 4930512..4932170 + 1659 WP_042783386.1 putative transporter -
I6I46_RS23595 4932181..4932561 - 381 WP_025304766.1 type II toxin-antitoxin system VapC family toxin Toxin
I6I46_RS23600 4932561..4932782 - 222 WP_025304767.1 ribbon-helix-helix domain-containing protein Antitoxin
I6I46_RS23605 4932856..4934106 - 1251 WP_047025992.1 valine--pyruvate transaminase -
I6I46_RS23610 4935119..4935898 + 780 WP_033645137.1 2OG-Fe dioxygenase family protein -
I6I46_RS23615 4935978..4937117 + 1140 WP_046687995.1 PLP-dependent aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T186854 WP_025304766.1 NZ_CP068214:c4932561-4932181 [Serratia ureilytica]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T186854 NZ_CP089773:2871650-2872027 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTACTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT186854 WP_025304767.1 NZ_CP068214:c4932782-4932561 [Serratia ureilytica]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp

>AT186854 NZ_CP089773:2871396-2871653 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GSJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GSF3

References