Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4932181..4932782 Replicon chromosome
Accession NZ_CP068214
Organism Serratia ureilytica strain FDAARGOS_1089

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag I6I46_RS23595 Protein ID WP_025304766.1
Coordinates 4932181..4932561 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag I6I46_RS23600 Protein ID WP_025304767.1
Coordinates 4932561..4932782 (-) Length 74 a.a.

Genomic Context

I6I46_RS23570I6I46_RS23580I6I46_RS23585I6I46_RS23590I6I46_RS23610I6I46_RS23615I6I46_RS23575I6I46_RS23595I6I46_RS23600I6I46_RS23605
Location: 4927428..4928708 (1281 bp)
Type: Others
Protein ID: WP_033652318.1
Location: 4929396..4929809 (414 bp)
Type: Others
Protein ID: WP_004933919.1
Location: 4929916..4930344 (429 bp)
Type: Others
Protein ID: WP_004933922.1
Location: 4930512..4932170 (1659 bp)
Type: Others
Protein ID: WP_042783386.1
Location: 4935119..4935898 (780 bp)
Type: Others
Protein ID: WP_033645137.1
Location: 4935978..4937117 (1140 bp)
Type: Others
Protein ID: WP_046687995.1
Location: 4928739..4929086 (348 bp)
Type: Others
Protein ID: WP_016929593.1
Location: 4932181..4932561 (381 bp)
Type: Toxin
Protein ID: WP_025304766.1
Location: 4932561..4932782 (222 bp)
Type: Antitoxin
Protein ID: WP_025304767.1
Location: 4932856..4934106 (1251 bp)
Type: Others
Protein ID: WP_047025992.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6I46_RS235704927428..4928708+1281WP_033652318.1DUF3748 domain-containing protein-
I6I46_RS235754928739..4929086-348WP_016929593.1YceK/YidQ family lipoprotein-
I6I46_RS235804929396..4929809+414WP_004933919.1heat shock chaperone IbpA-
I6I46_RS235854929916..4930344+429WP_004933922.1heat shock chaperone IbpB-
I6I46_RS235904930512..4932170+1659WP_042783386.1putative transporter-
I6I46_RS235954932181..4932561-381WP_025304766.1type II toxin-antitoxin system VapC family toxinToxin
I6I46_RS236004932561..4932782-222WP_025304767.1ribbon-helix-helix domain-containing proteinAntitoxin
I6I46_RS236054932856..4934106-1251WP_047025992.1valine--pyruvate transaminase-
I6I46_RS236104935119..4935898+780WP_033645137.12OG-Fe dioxygenase family protein-
I6I46_RS236154935978..4937117+1140WP_046687995.1PLP-dependent aspartate aminotransferase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T186854 WP_025304766.1 NZ_CP068214:c4932561-4932181 [Serratia ureilytica]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T186854 NZ_CP089773:2871650-2872027 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTACTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT186854 WP_025304767.1 NZ_CP068214:c4932782-4932561 [Serratia ureilytica]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp

>AT186854 NZ_CP089773:2871396-2871653 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A8B4GSJ7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A8B4GSF3

References