Detailed information of TA system TA186850

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3905965..3906634
• Replicon: chromosome
• Accession: NZ_CP068214
• Organism: Serratia ureilytica strain FDAARGOS_1089

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: I6I46_RS18720
• Protein ID: WP_033652168.1
• Coordinates: 3905965..3906387 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: I6I46_RS18725
• Protein ID: WP_019455657.1
• Coordinates: 3906368..3906634 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I46_RS18700	3901854..3902372	+	519	WP_033635825.1	flavodoxin FldB	-
I6I46_RS18705	3902410..3903774	-	1365	WP_033652165.1	cell envelope integrity protein CreD	-
I6I46_RS18710	3903855..3905273	-	1419	WP_160204551.1	two-component system sensor histidine kinase CreC	-
I6I46_RS18715	3905270..3905965	-	696	WP_047573795.1	two-component system response regulator CreB	-
I6I46_RS18720	3905965..3906387	-	423	WP_033652168.1	protein YgfX	Toxin
I6I46_RS18725	3906368..3906634	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
I6I46_RS18730	3906955..3907947	+	993	WP_033644775.1	tRNA-modifying protein YgfZ	-
I6I46_RS18735	3907986..3908483	-	498	WP_033644774.1	DUF2165 domain-containing protein	-
I6I46_RS18740	3908634..3909308	-	675	WP_033644772.1	hemolysin III family protein	-
I6I46_RS18745	3909492..3910100	+	609	WP_169539779.1	HD domain-containing protein	-
I6I46_RS18750	3910141..3911067	-	927	WP_033644768.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16482.55 Da
• Isoelectric Point: 10.6021

>T186850 WP_033652168.1 NZ_CP068214:c3906387-3905965 [Serratia ureilytica]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWQLAKKPWMPGYGLLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEEP

Nucleotide

• Length: 423 bp

>T186850 NZ_CP089773:c2405723-2405406 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT186850 WP_019455657.1 NZ_CP068214:c3906634-3906368 [Serratia ureilytica]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT186850 NZ_CP089773:c2405935-2405720 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04