Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1465718..1466243 Replicon chromosome
Accession NZ_CP068214
Organism Serratia ureilytica strain FDAARGOS_1089

Toxin (Protein)


Gene name relE Uniprot ID A0A8B4GJ35
Locus tag I6I46_RS07205 Protein ID WP_033633469.1
Coordinates 1465718..1466002 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag I6I46_RS07210 Protein ID WP_004928423.1
Coordinates 1465992..1466243 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I46_RS07180 1460922..1462055 + 1134 WP_069100891.1 putrescine ABC transporter ATP-binding subunit PotG -
I6I46_RS07185 1462080..1463042 + 963 WP_142002224.1 putrescine ABC transporter permease PotH -
I6I46_RS07190 1463039..1463884 + 846 WP_025302238.1 putrescine ABC transporter permease PotI -
I6I46_RS07195 1464046..1464525 + 480 WP_047024958.1 YbjO family protein -
I6I46_RS07200 1464594..1465721 + 1128 WP_033650649.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
I6I46_RS07205 1465718..1466002 - 285 WP_033633469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I46_RS07210 1465992..1466243 - 252 WP_004928423.1 prevent-host-death protein Antitoxin
I6I46_RS07215 1466345..1467079 - 735 WP_015377297.1 arginine ABC transporter substrate-binding protein -
I6I46_RS07220 1467280..1467948 - 669 WP_033650651.1 arginine ABC transporter permease ArtM -
I6I46_RS07225 1467948..1468664 - 717 WP_025159684.1 arginine ABC transporter permease ArtQ -
I6I46_RS07230 1468674..1469405 - 732 WP_033642533.1 arginine ABC transporter substrate-binding protein -
I6I46_RS07235 1469438..1470166 - 729 WP_089192582.1 arginine ABC transporter ATP-binding protein ArtP -
I6I46_RS07240 1470431..1470973 - 543 WP_033642535.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10789.91 Da        Isoelectric Point: 10.6941

>T186840 WP_033633469.1 NZ_CP068214:c1466002-1465718 [Serratia ureilytica]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

>T186840 NZ_CP089773:1977106-1977354 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT186840 WP_004928423.1 NZ_CP068214:c1466243-1465992 [Serratia ureilytica]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT186840 NZ_CP089773:1976894-1977106 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GJ35

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References