Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 796874..797496 Replicon chromosome
Accession NZ_CP068214
Organism Serratia ureilytica strain FDAARGOS_1089

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag I6I46_RS03830 Protein ID WP_004940313.1
Coordinates 796874..797077 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag I6I46_RS03835 Protein ID WP_004940312.1
Coordinates 797128..797496 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I46_RS03805 792683..793177 + 495 WP_046688369.1 type II secretion system protein M -
I6I46_RS03810 793162..793977 + 816 WP_046688370.1 A24 family peptidase -
I6I46_RS03815 793974..794336 - 363 WP_052752709.1 type II secretion system pilot lipoprotein GspS -
I6I46_RS03820 794594..796021 + 1428 WP_046688371.1 N-acetylglucosamine-binding protein GbpA -
I6I46_RS03825 796074..796592 + 519 WP_142075110.1 cytochrome b/b6 domain-containing protein -
I6I46_RS03830 796874..797077 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
I6I46_RS03835 797128..797496 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
I6I46_RS03840 797656..798009 - 354 WP_047025751.1 hypothetical protein -
I6I46_RS03845 798419..799132 + 714 WP_169539415.1 ABC transporter ATP-binding protein -
I6I46_RS03850 799129..799986 + 858 WP_047572431.1 metal ABC transporter permease -
I6I46_RS03855 800012..800890 + 879 WP_169539416.1 metal ABC transporter substrate-binding protein -
I6I46_RS03860 800996..801136 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
I6I46_RS03865 801149..801403 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T186839 WP_004940313.1 NZ_CP068214:c797077-796874 [Serratia ureilytica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T186839 NZ_CP089773:c1956665-1956276 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT186839 WP_004940312.1 NZ_CP068214:c797496-797128 [Serratia ureilytica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT186839 NZ_CP089773:c1956889-1956662 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References