Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 6514758..6515322 Replicon chromosome
Accession NZ_CP068211
Organism Achromobacter xylosoxidans strain FDAARGOS_1091

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6IHV7
Locus tag I6I48_RS30355 Protein ID WP_020926667.1
Coordinates 6514758..6515039 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6IHW1
Locus tag I6I48_RS30360 Protein ID WP_020926666.1
Coordinates 6515026..6515322 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I48_RS30330 6509789..6510292 - 504 WP_006386642.1 flavin reductase family protein -
I6I48_RS30335 6510316..6511329 - 1014 WP_049051052.1 LLM class flavin-dependent oxidoreductase -
I6I48_RS30340 6511451..6512284 + 834 WP_054483102.1 IclR family transcriptional regulator -
I6I48_RS30345 6512520..6513575 + 1056 WP_054483104.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
I6I48_RS30350 6513572..6514708 + 1137 WP_054483106.1 tRNA guanosine(34) transglycosylase Tgt -
I6I48_RS30355 6514758..6515039 - 282 WP_020926667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I48_RS30360 6515026..6515322 - 297 WP_020926666.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6I48_RS30365 6515695..6516039 + 345 WP_006386647.1 preprotein translocase subunit YajC -
I6I48_RS30370 6516155..6518035 + 1881 WP_006386648.1 protein translocase subunit SecD -
I6I48_RS30375 6518087..6519022 + 936 WP_006386649.1 protein translocase subunit SecF -
I6I48_RS30380 6519284..6519559 + 276 WP_081397338.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6I48_RS30385 6519556..6519867 + 312 WP_006386651.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-52)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10262.77 Da        Isoelectric Point: 7.0080

>T186838 WP_020926667.1 NZ_CP068211:c6515039-6514758 [Achromobacter xylosoxidans]
VPAVEWSSAARADLLAIVDYISDDNPDAAQRLKDDIETKAAQLPARPALYRPGRIAGTREMVVRANYIIVYAADALAVRI
LRILHAAQQWPPQ

Download         Length: 282 bp

>T186838 NZ_CP089773:1772799-1773203 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10717.24 Da        Isoelectric Point: 7.3208

>AT186838 WP_020926666.1 NZ_CP068211:c6515322-6515026 [Achromobacter xylosoxidans]
MPQTSMLHVRVDDKLKADATEKLAEFGLTISDAVRILLTRVAKEGGLPAGLTTDAQAHDAWFRAKVQEALADTGPAVPHQ
QVMDEAQALIDRKRRARS

Download         Length: 297 bp

>AT186838 NZ_CP089773:1772590-1772793 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6IHV7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6IHW1

References