Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 5233687..5234351 Replicon chromosome
Accession NZ_CP068211
Organism Achromobacter xylosoxidans strain FDAARGOS_1091

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag I6I48_RS24435 Protein ID WP_026384545.1
Coordinates 5233687..5233872 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I6I48_RS24440 Protein ID WP_026384544.1
Coordinates 5233941..5234351 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I48_RS24405 5228978..5230318 - 1341 WP_051429192.1 phage portal protein -
I6I48_RS24410 5230318..5232015 - 1698 WP_026384549.1 terminase large subunit -
I6I48_RS24415 5232061..5232384 - 324 WP_035200871.1 hypothetical protein -
I6I48_RS24420 5232542..5232877 - 336 WP_026384548.1 HNH endonuclease -
I6I48_RS24425 5232880..5233275 - 396 WP_026384547.1 hypothetical protein -
I6I48_RS24430 5233279..5233488 - 210 WP_026384546.1 hypothetical protein -
I6I48_RS24435 5233687..5233872 + 186 WP_026384545.1 type II toxin-antitoxin system HicA family toxin Toxin
I6I48_RS24440 5233941..5234351 + 411 WP_026384544.1 transcriptional regulator Antitoxin
I6I48_RS24445 5234680..5234943 - 264 WP_026384543.1 hypothetical protein -
I6I48_RS24450 5235122..5235577 + 456 WP_026384542.1 hypothetical protein -
I6I48_RS24460 5235859..5236452 - 594 WP_026384541.1 hypothetical protein -
I6I48_RS24465 5236449..5236829 - 381 WP_026384540.1 hypothetical protein -
I6I48_RS24470 5237020..5237250 - 231 WP_026384539.1 hypothetical protein -
I6I48_RS24475 5237247..5239025 - 1779 WP_026384538.1 toprim domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5175728..5277212 101484


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6947.12 Da        Isoelectric Point: 10.9041

>T186837 WP_026384545.1 NZ_CP068211:5233687-5233872 [Achromobacter xylosoxidans]
MKYSEFRRWLLRQGVKLEAHKSGSSHFKATLGDRMTVFPDHGSKEMGTGLVNKIKKDLGLK

Download         Length: 186 bp

>T186837 NZ_CP089773:1694389-1694706 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14578.67 Da        Isoelectric Point: 4.8781

>AT186837 WP_026384544.1 NZ_CP068211:5233941-5234351 [Achromobacter xylosoxidans]
MLTYSYTLTPDTNGTYLIQYPDLPEGAAVSESPNAAAEAAEGLEAVLQMYIDARRPIPMPSGVGDGAVNVGAMRTAKVLL
SNEMVRQGVRKADLARRLGLHAPQVDRLLDLSHNSKMDAIEAACAELGRRLDVSLI

Download         Length: 411 bp

>AT186837 NZ_CP089773:1694090-1694392 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References