Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2053241..2053814 Replicon chromosome
Accession NZ_CP068211
Organism Achromobacter xylosoxidans strain FDAARGOS_1091

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I6I48_RS09560 Protein ID WP_049054629.1
Coordinates 2053437..2053814 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I6I48_RS09555 Protein ID WP_054471260.1
Coordinates 2053241..2053450 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I48_RS09535 2048647..2049435 - 789 WP_049054627.1 helix-turn-helix transcriptional regulator -
I6I48_RS09540 2049534..2050460 + 927 WP_020924995.1 DMT family transporter -
I6I48_RS09545 2050473..2051291 - 819 WP_054480704.1 AAC(3) family N-acetyltransferase -
I6I48_RS09550 2051443..2053116 + 1674 WP_054480706.1 energy-dependent translational throttle protein EttA -
I6I48_RS09555 2053241..2053450 + 210 WP_054471260.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
I6I48_RS09560 2053437..2053814 + 378 WP_049054629.1 type II toxin-antitoxin system VapC family toxin Toxin
I6I48_RS09565 2053882..2054415 + 534 WP_054480708.1 isochorismatase family protein -
I6I48_RS09570 2054606..2054830 + 225 WP_006388976.1 glycine zipper 2TM domain-containing protein -
I6I48_RS09575 2054960..2055217 - 258 WP_006388977.1 cell division topological specificity factor MinE -
I6I48_RS09580 2055221..2056036 - 816 WP_006388978.1 septum site-determining protein MinD -
I6I48_RS09585 2056225..2057142 - 918 WP_054439442.1 septum site-determining protein MinC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13846.11 Da        Isoelectric Point: 6.3721

>T186834 WP_049054629.1 NZ_CP068211:2053437-2053814 [Achromobacter xylosoxidans]
MILVDTSIWIDHLSDGEPCLVRLLEEESVLMHPFIAGELALGSLGRRDVVLGAMSLLPQVVRASHDEVMHFLHSERLFGK
GIGYVDLHLLASTRLTPGAALWTRDKRLQALATTLSLAVDPPRYH

Download         Length: 378 bp

>T186834 NZ_CP089773:c1396188-1395895 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7521.62 Da        Isoelectric Point: 9.9435

>AT186834 WP_054471260.1 NZ_CP068211:2053241-2053450 [Achromobacter xylosoxidans]
VRTTVTLDDDLLELARTYTGVQETSALVTRALTQLVQKEAAKRLAKLGGSSPKLKPIPRRQTETCNDPG

Download         Length: 210 bp

>AT186834 NZ_CP089773:c1396454-1396185 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References