Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 255848..257364 Replicon chromosome
Accession NZ_CP068211
Organism Achromobacter xylosoxidans strain FDAARGOS_1091

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag I6I48_RS01080 Protein ID WP_049058967.1
Coordinates 255848..257110 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag I6I48_RS01085 Protein ID WP_020926185.1
Coordinates 257107..257364 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I48_RS01070 252264..254447 + 2184 WP_054482530.1 TonB-dependent siderophore receptor -
I6I48_RS01075 254451..255650 - 1200 WP_006385726.1 MFS transporter -
I6I48_RS01080 255848..257110 - 1263 WP_049058967.1 type II toxin-antitoxin system HipA family toxin Toxin
I6I48_RS01085 257107..257364 - 258 WP_020926185.1 helix-turn-helix transcriptional regulator Antitoxin
I6I48_RS01090 257628..259517 - 1890 WP_054482529.1 molecular chaperone HtpG -
I6I48_RS01095 259719..261122 - 1404 WP_054482573.1 DKNYY domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - adeG 218193..442638 224445


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-75)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45607.99 Da        Isoelectric Point: 7.0531

>T186832 WP_049058967.1 NZ_CP068211:c257110-255848 [Achromobacter xylosoxidans]
MSTDALDLYQADRKVGRLFDERPLRFVYDDAWLGWPAAHAIAPDIPLRDGAHVGEAVHAFFENLLPEGRLRRFLQVSRHA
TTVFGLLRSVGGDTASGLTIWPQGERPAPPRYRGTTWGEIVARLQDPAQPALVAENADGARISLAGAQDKLLLMVMPDGS
PAWPEGAAPSTHILKPDIRGFDGVWSSALNETLVMQLAARLGLGVAEAGLQPDTRACLVTRYDRAPDGAGGLLRLHQLDL
CQLAGKSSDVKYEADGGPSLAHCRELLRGMGINAADLKRFLQWVLFNLCVGNNDSHAKNLSVLQTPDGQYRLAPFYDLMC
TALYPGLARNFAFAVGGESRPGHIGRGHLDAMARELGFSPRYVAGMAQALVTELPSALETVQADLARQAMAGTESTLVER
LGQWIRANTRKHAKRWELAG

Download         Length: 1263 bp

>T186832 NZ_CP089773:1245777-1246151 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9117.63 Da        Isoelectric Point: 8.8566

>AT186832 WP_020926185.1 NZ_CP068211:c257364-257107 [Achromobacter xylosoxidans]
MPSLSTADGLPIVIHTSAELGELVKDVRRAQGLLQTDLAGLSGTGNRFVVDLERGKPTLQLQKVLDMLDLLGLEVRVGPK
RVGRS

Download         Length: 258 bp

>AT186832 NZ_CP089773:1245583-1245780 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References