Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 375971..376620 Replicon chromosome
Accession NZ_CP068206
Organism Acinetobacter johnsonii strain FDAARGOS_1092

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I6I49_RS03700 Protein ID WP_201952335.1
Coordinates 375971..376390 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I6I49_RS03705 Protein ID WP_201952338.1
Coordinates 376390..376620 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I49_RS03665 371641..371913 - 273 WP_005400275.1 hypothetical protein -
I6I49_RS03670 372021..372686 - 666 WP_201953706.1 hypothetical protein -
I6I49_RS03675 372941..373294 + 354 Protein_359 hypothetical protein -
I6I49_RS03680 373376..373582 - 207 WP_005400272.1 hypothetical protein -
I6I49_RS03685 373814..374389 - 576 WP_201952332.1 DUF4126 domain-containing protein -
I6I49_RS03695 375697..375840 - 144 WP_004695201.1 zinc ribbon-containing protein -
I6I49_RS03700 375971..376390 - 420 WP_201952335.1 type II toxin-antitoxin system VapC family toxin Toxin
I6I49_RS03705 376390..376620 - 231 WP_201952338.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6I49_RS03715 377995..378636 - 642 Protein_367 hypothetical protein -
I6I49_RS03720 378690..379028 - 339 WP_017395859.1 transposase -
I6I49_RS03725 379120..379524 - 405 WP_201952342.1 transposase family protein -
I6I49_RS03730 379610..380275 - 666 WP_201952345.1 DUF4935 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 374455..377860 3405


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16157.55 Da        Isoelectric Point: 6.3762

>T186830 WP_201952335.1 NZ_CP068206:c376390-375971 [Acinetobacter johnsonii]
MQTQYLLDTNICIYIIKHQPEIVRQHFEKHLPHRNILISVITLGELRFGAEKSQQKEKALKVIDELTSMIQVVELDEYVA
DHYAQIRHDLSSKGQIIGANDLWLAAHARANNWVMVTNNEKEFLRVDGLQIENWVSNIL

Download         Length: 420 bp

>T186830 NZ_CP089773:1173968-1174849 [Mycobacterium tuberculosis]
GTGACCAAGCCCTATTCGTCGCCGCCAACGAACCTGCGCTCACTACGAGATCGGCTCACCCAAGTAGCGGAACGGCAAGG
TGTCGTGTTCGGTCGACTGCAGCGGCATGTCGCGATGATTGTTGTCGCACAGTTCGCGGCCACGCTCACCGACGACACCG
GCGCTCCGCTGCTGTTGGTCAAAGGCGGATCGTCGCTGGAACTGCGCCGGGGAATTCCCGATTCGCGGACCTCCAAAGAC
TTCGACACGGTCGCACGTCGCGATATCGAATTAATCCATGAACAGCTCGCTGACGCGGGCGAGACGGGGTGGGAAGGATT
CACTGCAATCTTCACCGCCCCCGAAGAAATCGATGTTCCTGGTATGCCGGTCAAGCCGCGCCGATTCACCGCCAAGCTGA
GCTACCGAGGCCGGGCTTTCGCAACTGTTCCGATCGAGGTCTCCTCCGTCGAAGCCGGCAATGCCGACCAATTCGACACC
CTCACCTCAGACGCGCTCGGCCTCGTGGGCGTACCCGCAGCAGTCGCCGTACCCTGCATGACCATTCCCTGGCAAATCGC
GCAGAAGCTGCACGCAGTAACTGCCGTGCTCGAAGAACCGAAGGTCAACGACCGCGCTCACGACCTGGTGGACTTGCAGC
TTCTTGAAGGACTGTTGCTCGATGCCGACCTCATGCCGACGCGCAGCGCGTGCATCGCGATATTCGAAGCGCGCGCCCAG
CATCCTTGGCCACCGAGAGTCGCCACGCTGCCGCACTGGCCGCTGATCTATGCAGGTGCGCTGGAGGGGCTTGACCACCT
TGAACTCGCCAGGACGGTCGACGCGGCGGCCCAGGCAGTGCAGCGATTCGTTGCGCGGATTGATCGGGCGACGAAAAGAT
GA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9023.27 Da        Isoelectric Point: 4.7049

>AT186830 WP_201952338.1 NZ_CP068206:c376620-376390 [Acinetobacter johnsonii]
MTTAKVFMSGRSQAVRLPKEFRFEGTEVEIFRRGDEVILREKPVTVDRLFKVLAQMPNDFYAEERVDEPPQEREEF

Download         Length: 231 bp

>AT186830 NZ_CP089773:1173348-1173971 [Mycobacterium tuberculosis]
TTGTGTGCAAAACCGTATCTAATTGATACGATTGCGCACATGGCTATCTGGGATCGCCTCGTCGAGGTTGCCGCCGAGCA
ACATGGCTACGTCACGACTCGCGATGCGCGAGACATCGGCGTCGACCCTGTGCAGCTCCGCCTCCTAGCGGGGCGCGGAC
GTCTTGAGCGTGTCGGCCGAGGTGTGTACCGGGTGCCCGTGCTGCCGCGTGGTGAGCACGACGATCTCGCAGCCGCAGTG
TCGTGGACTTTGGGGCGTGGCGTTATCTCGCATGAGTCGGCCTTGGCGCTTCATGCCCTCGCTGACGTGAACCCGTCGCG
CATCCATCTCACCGTCCCGCGCAACAACCATCCGCGTGCGGCCGGGGGCGAGCTGTACCGAGTTCACCGCCGCGACCTCC
AGGCAGCCCACGTCACTTCGGTCGACGGAATACCCGTCACGACGGTTGCGCGCACCATCAAAGACTGCGTGAAGACGGGC
ACGGATCCTTATCAGCTTCGGGCCGCGATCGAGCGAGCCGAAGCCGAGGGCACGCTTCGTCGTGGGTCAGCAGCTGAGCT
ACGCGCTGCGCTCGATGAGACCACTGCCGGATTACGCGCTCGGCCGAAGCGAGCATCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References