Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 65801..66423 Replicon plasmid unnamed1
Accession NZ_CP068202
Organism Acinetobacter johnsonii strain FDAARGOS_1092

Toxin (Protein)


Gene name vapC Uniprot ID R9BAE0
Locus tag I6I49_RS00365 Protein ID WP_000639719.1
Coordinates 66028..66423 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R9B9I8
Locus tag I6I49_RS00360 Protein ID WP_000401521.1
Coordinates 65801..66031 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I49_RS00345 61614..62036 - 423 Protein_68 site-specific integrase -
I6I49_RS00350 62053..63081 - 1029 WP_201949806.1 transposase -
I6I49_RS00355 63887..65220 + 1334 Protein_70 ISNCY family transposase -
I6I49_RS00360 65801..66031 + 231 WP_000401521.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6I49_RS00365 66028..66423 + 396 WP_000639719.1 type II toxin-antitoxin system VapC family toxin Toxin
I6I49_RS00370 66584..67015 + 432 WP_004763240.1 hypothetical protein -
I6I49_RS00375 67194..68135 + 942 Protein_74 IS5 family transposase -
I6I49_RS00380 68247..69971 - 1725 WP_000751934.1 bifunctional protein-serine/threonine kinase/phosphatase -
I6I49_RS00385 70023..70832 - 810 WP_000323725.1 formate/nitrite transporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..183617 183617
- inside IScluster/Tn - - 60630..98876 38246


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-37)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14897.19 Da        Isoelectric Point: 6.4640

>T186828 WP_000639719.1 NZ_CP068202:66028-66423 [Acinetobacter johnsonii]
MIYLLDTNICIYVINNKPQQVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLEILPYDEQAIWHYA
KLRQNLQSTGKPIGSLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWV

Download         Length: 396 bp

>T186828 NZ_CP089773:846444-846872 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8759.04 Da        Isoelectric Point: 4.7708

>AT186828 WP_000401521.1 NZ_CP068202:65801-66031 [Acinetobacter johnsonii]
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAINEFEVGFQLERADQGEQLREEFR

Download         Length: 231 bp

>AT186828 NZ_CP089773:846163-846420 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N6V6E5

Antitoxin

Source ID Structure
AlphaFold DB A0A2N6V6E6

References