Detailed information of TA system TA186822

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 877552..878080
• Replicon: chromosome
• Accession: NZ_CP068195
• Organism: Acinetobacter johnsonii strain FDAARGOS_1093

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I6I50_RS04430
• Protein ID: WP_119686978.1
• Coordinates: 877787..878080 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N9B5Q7
• Locus tag: I6I50_RS04425
• Protein ID: WP_000246756.1
• Coordinates: 877552..877797 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I50_RS04410	872702..874036	+	1335	WP_010326716.1	ISNCY family transposase	-
I6I50_RS04415	874696..876216	+	1521	WP_005249302.1	catalase	-
I6I50_RS04420	876398..877345	+	948	WP_126034964.1	sensor domain-containing diguanylate cyclase	-
I6I50_RS04425	877552..877797	+	246	WP_000246756.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I6I50_RS04430	877787..878080	+	294	WP_119686978.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6I50_RS04435	878472..879544	+	1073	Protein_849	IS3 family transposase	-
I6I50_RS04440	879572..879910	-	339	WP_178896424.1	transposase	-
I6I50_RS04445	880002..880406	-	405	WP_004730644.1	transposase family protein	-
I6I50_RS04450	880628..881542	+	915	WP_201707174.1	hypothetical protein	-
I6I50_RS04455	881539..882003	+	465	WP_126034954.1	hypothetical protein	-
I6I50_RS04460	881990..882616	+	627	WP_126034952.1	hypothetical protein	-
I6I50_RS04465	882681..882995	-	315	WP_126034950.1	BrnA antitoxin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	katA	851950..895504	43554
	-	inside	IScluster/Tn	-	katA	872702..884865	12163

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11319.59 Da
• Isoelectric Point: 10.5382

>T186822 WP_119686978.1 NZ_CP068195:877787-878080 [Acinetobacter johnsonii]
MTYKLLRHKDFKAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T186822 NZ_CP089773:721185-721580 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9235.61 Da
• Isoelectric Point: 4.3142

>AT186822 WP_000246756.1 NZ_CP068195:877552-877797 [Acinetobacter johnsonii]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT186822 NZ_CP089773:720931-721185 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Structures

Antitoxin

• AlphaFold DB: N9B5Q7