Detailed information of TA system TA186821

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 663771..664420
• Replicon: chromosome
• Accession: NZ_CP068195
• Organism: Acinetobacter johnsonii strain FDAARGOS_1093

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: I6I50_RS03315
• Protein ID: WP_201706812.1
• Coordinates: 663771..664157 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9CU98
• Locus tag: I6I50_RS03320
• Protein ID: WP_004977895.1
• Coordinates: 664163..664420 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I50_RS03295	659104..661386	-	2283	WP_201706809.1	TRAP transporter large permease subunit	-
I6I50_RS03300	661569..662141	-	573	WP_201706810.1	rhombosortase	-
I6I50_RS03305	662213..662776	-	564	WP_171293170.1	hypothetical protein	-
I6I50_RS03310	662773..663015	-	243	WP_201706811.1	hypothetical protein	-
I6I50_RS03315	663771..664157	-	387	WP_201706812.1	hypothetical protein	Toxin
I6I50_RS03320	664163..664420	-	258	WP_004977895.1	succinate dehydrogenase assembly factor 2	Antitoxin
I6I50_RS03325	664613..665785	+	1173	WP_201706813.1	acyl-CoA dehydrogenase family protein	-
I6I50_RS03330	665823..667124	-	1302	WP_039891156.1	IS4 family transposase	-
I6I50_RS03335	667221..668004	-	784	Protein_632	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-127)

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15268.27 Da
• Isoelectric Point: 10.4419

>T186821 WP_201706812.1 NZ_CP068195:c664157-663771 [Acinetobacter johnsonii]
MEHRHFQLKPSRLAYVFQLSIYAVLMLVLYQLLPLGVWLIALVAGFVLYLFFLRGPQHLQLQHLDGRDWSLSLQKQTNVQ
RVQISHIVDHRAYIVIYFQHFRAKPMLVWCDQLPITQWKALKILTKMQ

Nucleotide

• Length: 387 bp

>T186821 NZ_CP089773:715527-715928 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10181.71 Da
• Isoelectric Point: 4.7119

>AT186821 WP_004977895.1 NZ_CP068195:c664420-664163 [Acinetobacter johnsonii]
MTEEMSLEERKVIYRARRGLKEIDVYFDPYVKNYYLQADPAEKAMFAALVEQEDPDLLDWFMEVSEPPRPEMKTLIQKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT186821 NZ_CP089773:715303-715530 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Structures

Antitoxin

• AlphaFold DB: N9CU98