Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc(toxin) |
Location | 407413..407975 | Replicon | chromosome |
Accession | NZ_CP068195 | ||
Organism | Acinetobacter johnsonii strain FDAARGOS_1093 |
Toxin (Protein)
Gene name | doc | Uniprot ID | - |
Locus tag | I6I50_RS02030 | Protein ID | WP_125280299.1 |
Coordinates | 407413..407805 (-) | Length | 131 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | - |
Locus tag | I6I50_RS02035 | Protein ID | WP_125280298.1 |
Coordinates | 407805..407975 (-) | Length | 57 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6I50_RS01990 | 402525..403100 | - | 576 | WP_004695203.1 | DUF4126 domain-containing protein | - |
I6I50_RS01995 | 403219..403362 | - | 144 | WP_004695201.1 | zinc ribbon-containing protein | - |
I6I50_RS02000 | 403553..403726 | - | 174 | WP_201706716.1 | hypothetical protein | - |
I6I50_RS02005 | 403949..404272 | + | 324 | WP_201706717.1 | transposase family protein | - |
I6I50_RS02010 | 404312..404701 | + | 390 | WP_079270576.1 | transposase | - |
I6I50_RS02015 | 404875..405915 | - | 1041 | WP_004642076.1 | IS481 family transposase | - |
I6I50_RS02020 | 406026..406979 | - | 954 | WP_201706718.1 | DUF4062 domain-containing protein | - |
I6I50_RS02025 | 407010..407231 | - | 222 | WP_201706719.1 | hypothetical protein | - |
I6I50_RS02030 | 407413..407805 | - | 393 | WP_125280299.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
I6I50_RS02035 | 407805..407975 | - | 171 | WP_125280298.1 | acetyltransferase | Antitoxin |
I6I50_RS02040 | 408050..410656 | - | 2607 | WP_201706720.1 | Fe/S-dependent 2-methylisocitrate dehydratase AcnD | - |
I6I50_RS02045 | 410918..411640 | + | 723 | WP_201706721.1 | folate-binding Fe/S cluster repair protein | - |
I6I50_RS02050 | 411714..412904 | - | 1191 | WP_201706722.1 | glucose/sorbosone dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 404875..405915 | 1040 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 14069.88 Da Isoelectric Point: 4.0582
>T186820 WP_125280299.1 NZ_CP068195:c407805-407413 [Acinetobacter johnsonii]
MNIICFPFERVIEINAFILATEKGMKGASDVGKLQGALARVDNAIVYEGLDDVFEIAAKYASSIANAHALSDANKRTGLA
VALEYLSLNDYELLQDNELLADAVRDLVIGEVTENDFADILYAHYVANGG
MNIICFPFERVIEINAFILATEKGMKGASDVGKLQGALARVDNAIVYEGLDDVFEIAAKYASSIANAHALSDANKRTGLA
VALEYLSLNDYELLQDNELLADAVRDLVIGEVTENDFADILYAHYVANGG
Download Length: 393 bp
>T186820 NZ_CP089773:708007-708408 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6316.39 Da Isoelectric Point: 10.9041
>AT186820 WP_125280298.1 NZ_CP068195:c407975-407805 [Acinetobacter johnsonii]
MNKKVEKYGVAAVERPKIQATKQLDLSGDTGRQIVKSETKLALRTHSKTFKRLADM
MNKKVEKYGVAAVERPKIQATKQLDLSGDTGRQIVKSETKLALRTHSKTFKRLADM
Download Length: 171 bp
>AT186820 NZ_CP089773:707765-708010 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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