Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 407413..407975 Replicon chromosome
Accession NZ_CP068195
Organism Acinetobacter johnsonii strain FDAARGOS_1093

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag I6I50_RS02030 Protein ID WP_125280299.1
Coordinates 407413..407805 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag I6I50_RS02035 Protein ID WP_125280298.1
Coordinates 407805..407975 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I50_RS01990 402525..403100 - 576 WP_004695203.1 DUF4126 domain-containing protein -
I6I50_RS01995 403219..403362 - 144 WP_004695201.1 zinc ribbon-containing protein -
I6I50_RS02000 403553..403726 - 174 WP_201706716.1 hypothetical protein -
I6I50_RS02005 403949..404272 + 324 WP_201706717.1 transposase family protein -
I6I50_RS02010 404312..404701 + 390 WP_079270576.1 transposase -
I6I50_RS02015 404875..405915 - 1041 WP_004642076.1 IS481 family transposase -
I6I50_RS02020 406026..406979 - 954 WP_201706718.1 DUF4062 domain-containing protein -
I6I50_RS02025 407010..407231 - 222 WP_201706719.1 hypothetical protein -
I6I50_RS02030 407413..407805 - 393 WP_125280299.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
I6I50_RS02035 407805..407975 - 171 WP_125280298.1 acetyltransferase Antitoxin
I6I50_RS02040 408050..410656 - 2607 WP_201706720.1 Fe/S-dependent 2-methylisocitrate dehydratase AcnD -
I6I50_RS02045 410918..411640 + 723 WP_201706721.1 folate-binding Fe/S cluster repair protein -
I6I50_RS02050 411714..412904 - 1191 WP_201706722.1 glucose/sorbosone dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 404875..405915 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(37-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14069.88 Da        Isoelectric Point: 4.0582

>T186820 WP_125280299.1 NZ_CP068195:c407805-407413 [Acinetobacter johnsonii]
MNIICFPFERVIEINAFILATEKGMKGASDVGKLQGALARVDNAIVYEGLDDVFEIAAKYASSIANAHALSDANKRTGLA
VALEYLSLNDYELLQDNELLADAVRDLVIGEVTENDFADILYAHYVANGG

Download         Length: 393 bp

>T186820 NZ_CP089773:708007-708408 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6316.39 Da        Isoelectric Point: 10.9041

>AT186820 WP_125280298.1 NZ_CP068195:c407975-407805 [Acinetobacter johnsonii]
MNKKVEKYGVAAVERPKIQATKQLDLSGDTGRQIVKSETKLALRTHSKTFKRLADM

Download         Length: 171 bp

>AT186820 NZ_CP089773:707765-708010 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References