Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 3037053..3037615 Replicon chromosome
Accession NZ_CP068187
Organism Acinetobacter johnsonii strain FDAARGOS_1094

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag I6I51_RS15280 Protein ID WP_125280299.1
Coordinates 3037223..3037615 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag I6I51_RS15275 Protein ID WP_125280298.1
Coordinates 3037053..3037223 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I51_RS15265 3033376..3034098 - 723 WP_125280296.1 folate-binding Fe/S cluster repair protein -
I6I51_RS15270 3034360..3036978 + 2619 WP_201702571.1 Fe/S-dependent 2-methylisocitrate dehydratase AcnD -
I6I51_RS15275 3037053..3037223 + 171 WP_125280298.1 acetyltransferase Antitoxin
I6I51_RS15280 3037223..3037615 + 393 WP_125280299.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
I6I51_RS15285 3037798..3039561 + 1764 WP_075695922.1 AAA family ATPase -
I6I51_RS15290 3039669..3039812 + 144 WP_004637424.1 zinc ribbon-containing protein -
I6I51_RS15295 3040153..3040296 + 144 WP_004695201.1 zinc ribbon-containing protein -
I6I51_RS15300 3040415..3040990 + 576 WP_201702572.1 DUF4126 domain-containing protein -
I6I51_RS15305 3041223..3041429 + 207 WP_004695205.1 hypothetical protein -
I6I51_RS15310 3041511..3041864 - 354 WP_201702573.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(37-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14069.88 Da        Isoelectric Point: 4.0582

>T186818 WP_125280299.1 NZ_CP068187:3037223-3037615 [Acinetobacter johnsonii]
MNIICFPFERVIEINAFILATEKGMKGASDVGKLQGALARVDNAIVYEGLDDVFEIAAKYASSIANAHALSDANKRTGLA
VALEYLSLNDYELLQDNELLADAVRDLVIGEVTENDFADILYAHYVANGG

Download         Length: 393 bp

>T186818 NZ_CP089773:c699872-699480 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6316.39 Da        Isoelectric Point: 10.9041

>AT186818 WP_125280298.1 NZ_CP068187:3037053-3037223 [Acinetobacter johnsonii]
MNKKVEKYGVAAVERPKIQATKQLDLSGDTGRQIVKSETKLALRTHSKTFKRLADM

Download         Length: 171 bp

>AT186818 NZ_CP089773:c700126-699869 [Mycobacterium tuberculosis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References