Detailed information of TA system TA186817

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1818680..1819329
• Replicon: chromosome
• Accession: NZ_CP068187
• Organism: Acinetobacter johnsonii strain FDAARGOS_1094

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8E1ZP63
• Locus tag: I6I51_RS09505
• Protein ID: WP_062032505.1
• Coordinates: 1818680..1819066 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9CU98
• Locus tag: I6I51_RS09510
• Protein ID: WP_004977895.1
• Coordinates: 1819072..1819329 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I51_RS09490	1814013..1816295	-	2283	WP_201701661.1	TRAP transporter large permease subunit	-
I6I51_RS09495	1816478..1817050	-	573	WP_004977887.1	rhombosortase	-
I6I51_RS09500	1817122..1818159	-	1038	WP_004977889.1	hypothetical protein	-
I6I51_RS09505	1818680..1819066	-	387	WP_062032505.1	hypothetical protein	Toxin
I6I51_RS09510	1819072..1819329	-	258	WP_004977895.1	succinate dehydrogenase assembly factor 2	Antitoxin
I6I51_RS09515	1819522..1820694	+	1173	WP_125280252.1	acyl-CoA dehydrogenase family protein	-
I6I51_RS09520	1820730..1821521	-	792	Protein_1780	alpha/beta hydrolase	-
I6I51_RS09525	1821653..1823143	-	1491	WP_201701663.1	NAD(P)/FAD-dependent oxidoreductase	-
I6I51_RS09530	1823339..1823704	-	366	WP_004691290.1	50S ribosomal protein L17	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-127)

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15316.31 Da
• Isoelectric Point: 10.4419

>T186817 WP_062032505.1 NZ_CP068187:c1819066-1818680 [Acinetobacter johnsonii]
MEHRHFQLKPSRLAYVFQLSIYAVLMLVLYQLLPLGLWLIALVAGFVLYLFFLRGPQHFQLQHLDGRDWSLSLQKQTNVQ
RVQISHIVDHRAYIVIYFQHFRAKPMLVWCDQLPITQWKALKILTKMQ

Nucleotide

• Length: 387 bp

>T186817 NZ_CP089773:682563-682970 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10181.71 Da
• Isoelectric Point: 4.7119

>AT186817 WP_004977895.1 NZ_CP068187:c1819329-1819072 [Acinetobacter johnsonii]
MTEEMSLEERKVIYRARRGLKEIDVYFDPYVKNYYLQADPAEKAMFAALVEQEDPDLLDWFMEVSEPPRPEMKTLIQKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT186817 NZ_CP089773:682351-682566 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Structures

Antitoxin

• AlphaFold DB: N9CU98