186816

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 46781..47403 Replicon plasmid unnamed1
Accession NZ_CP068185
Organism Acinetobacter johnsonii strain FDAARGOS_1094

Toxin (Protein)


Gene name vapC Uniprot ID R9BAE0
Locus tag I6I51_RS00255 Protein ID WP_000639719.1
Coordinates 47008..47403 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R9B9I8
Locus tag I6I51_RS00250 Protein ID WP_000401521.1
Coordinates 46781..47011 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I51_RS00220 42268..43200 + 933 WP_201701524.1 IS5 family transposase -
I6I51_RS00225 43389..43601 - 213 WP_125281854.1 hypothetical protein -
I6I51_RS00230 43698..43949 + 252 WP_125281855.1 hypothetical protein -
I6I51_RS00235 44182..44343 + 162 WP_201701554.1 hypothetical protein -
I6I51_RS00240 44368..44628 + 261 WP_201701527.1 hypothetical protein -
I6I51_RS00245 44867..46200 + 1334 Protein_48 ISNCY family transposase -
I6I51_RS00250 46781..47011 + 231 WP_000401521.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6I51_RS00255 47008..47403 + 396 WP_000639719.1 type II toxin-antitoxin system VapC family toxin Toxin
I6I51_RS00260 47512..48213 - 702 Protein_51 IS1 family transposase -
I6I51_RS00265 48273..48962 + 690 Protein_52 ISNCY family transposase -
I6I51_RS00270 49405..49845 - 441 WP_033917441.1 ribbon-helix-helix protein, CopG family -
I6I51_RS00275 50015..50242 - 228 Protein_54 NAD(P)H-dependent oxidoreductase -
I6I51_RS00280 50243..50417 + 175 Protein_55 DDE-type integrase/transposase/recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..50463 50463
- inside IScluster/Tn - - 28987..48962 19975


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-37)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14897.19 Da        Isoelectric Point: 6.4640

>T186816 WP_000639719.1 NZ_CP068185:47008-47403 [Acinetobacter johnsonii]
MIYLLDTNICIYVINNKPQQVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLEILPYDEQAIWHYA
KLRQNLQSTGKPIGSLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWV

Download         Length: 396 bp

>T186816 NZ_CP089773:c645291-644878 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8759.04 Da        Isoelectric Point: 4.7708

>AT186816 WP_000401521.1 NZ_CP068185:46781-47011 [Acinetobacter johnsonii]
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAINEFEVGFQLERADQGEQLREEFR

Download         Length: 231 bp

>AT186816 NZ_CP089773:c645554-645288 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N6V6E5

Antitoxin

Source ID Structure
AlphaFold DB A0A2N6V6E6

References