Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 12627..13249 Replicon plasmid unnamed2
Accession NZ_CP068182
Organism Acinetobacter ursingii strain FDAARGOS_1095

Toxin (Protein)


Gene name vapC Uniprot ID R9BAE0
Locus tag I6I52_RS16595 Protein ID WP_000639719.1
Coordinates 12854..13249 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R9B9I8
Locus tag I6I52_RS16590 Protein ID WP_000401521.1
Coordinates 12627..12857 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I52_RS16565 8160..8593 - 434 Protein_8 transposase -
I6I52_RS16570 8797..9048 - 252 WP_004986445.1 hypothetical protein -
I6I52_RS16575 9244..9465 + 222 WP_035245357.1 helix-turn-helix transcriptional regulator -
I6I52_RS16580 9709..10506 - 798 Protein_11 IS5 family transposase -
I6I52_RS16585 10714..12046 + 1333 Protein_12 ISNCY family transposase -
I6I52_RS16590 12627..12857 + 231 WP_000401521.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6I52_RS16595 12854..13249 + 396 WP_000639719.1 type II toxin-antitoxin system VapC family toxin Toxin
I6I52_RS16600 13469..14431 + 963 WP_004986464.1 IS30-like element IS18 family transposase -
I6I52_RS16605 14487..14912 + 426 WP_004986461.1 hypothetical protein -
I6I52_RS16610 15040..16373 - 1334 Protein_17 ISNCY family transposase -
I6I52_RS16615 16547..16978 + 432 WP_004986465.1 Arc family DNA-binding protein -
I6I52_RS16620 17032..17277 + 246 WP_004678286.1 hypothetical protein -
I6I52_RS16625 17286..17609 + 324 WP_004678285.1 toxin-antitoxin system HicB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..75090 75090
- inside IScluster/Tn - - 65..18984 18919


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-37)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14897.19 Da        Isoelectric Point: 6.4640

>T186815 WP_000639719.1 NZ_CP068182:12854-13249 [Acinetobacter ursingii]
MIYLLDTNICIYVINNKPQQVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLEILPYDEQAIWHYA
KLRQNLQSTGKPIGSLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWV

Download         Length: 396 bp

>T186815 NZ_CP089773:c449327-448734 [Mycobacterium tuberculosis]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8759.04 Da        Isoelectric Point: 4.7708

>AT186815 WP_000401521.1 NZ_CP068182:12627-12857 [Acinetobacter ursingii]
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAINEFEVGFQLERADQGEQLREEFR

Download         Length: 231 bp

>AT186815 NZ_CP089773:c449745-449356 [Mycobacterium tuberculosis]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N6V6E5

Antitoxin

Source ID Structure
AlphaFold DB A0A2N6V6E6

References