Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1131..1753 Replicon plasmid unnamed2
Accession NZ_CP068177
Organism Acinetobacter ursingii strain FDAARGOS_1096

Toxin (Protein)


Gene name vapC Uniprot ID R9BAE0
Locus tag I6I53_RS16125 Protein ID WP_000639719.1
Coordinates 1358..1753 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R9B9I8
Locus tag I6I53_RS16120 Protein ID WP_000401521.1
Coordinates 1131..1361 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I53_RS16120 1131..1361 + 231 WP_000401521.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6I53_RS16125 1358..1753 + 396 WP_000639719.1 type II toxin-antitoxin system VapC family toxin Toxin
I6I53_RS16130 1973..2935 + 963 WP_104795254.1 IS30-like element IS18 family transposase -
I6I53_RS16135 2991..3416 + 426 WP_004986461.1 hypothetical protein -
I6I53_RS16140 3544..4877 - 1334 Protein_5 ISNCY family transposase -
I6I53_RS16145 5051..5482 + 432 WP_004986465.1 Arc family DNA-binding protein -
I6I53_RS16150 5536..5781 + 246 WP_004678286.1 hypothetical protein -
I6I53_RS16155 5790..6113 + 324 WP_004678285.1 toxin-antitoxin system HicB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..74837 74837
- inside IScluster/Tn - - 8..7488 7480


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-37)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14897.19 Da        Isoelectric Point: 6.4640

>T186813 WP_000639719.1 NZ_CP068177:1358-1753 [Acinetobacter ursingii]
MIYLLDTNICIYVINNKPQQVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLEILPYDEQAIWHYA
KLRQNLQSTGKPIGSLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWV

Download         Length: 396 bp

>T186813 NZ_CP089773:367952-368254 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8759.04 Da        Isoelectric Point: 4.7708

>AT186813 WP_000401521.1 NZ_CP068177:1131-1361 [Acinetobacter ursingii]
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAINEFEVGFQLERADQGEQLREEFR

Download         Length: 231 bp

>AT186813 NZ_CP089773:368302-368523 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N6V6E5

Antitoxin

Source ID Structure
AlphaFold DB A0A2N6V6E6

References