186811

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 63204..63792 Replicon plasmid unnamed1
Accession NZ_CP068175
Organism Acinetobacter ursingii strain FDAARGOS_1096

Toxin (Protein)


Gene name brnT Uniprot ID A0A7T9Z5H4
Locus tag I6I53_RS00305 Protein ID WP_048765058.1
Coordinates 63204..63434 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9AKX6
Locus tag I6I53_RS00310 Protein ID WP_004942855.1
Coordinates 63478..63792 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I53_RS00285 58952..59719 - 768 WP_004999939.1 SDR family oxidoreductase -
I6I53_RS00290 59797..61095 - 1299 WP_004942636.1 MFS transporter -
I6I53_RS00295 61259..61981 - 723 Protein_58 ISNCY family transposase -
I6I53_RS00300 62120..62893 - 774 WP_004942631.1 alpha/beta hydrolase -
I6I53_RS00305 63204..63434 + 231 WP_048765058.1 BrnT family toxin Toxin
I6I53_RS00310 63478..63792 + 315 WP_004942855.1 BrnA antitoxin family protein Antitoxin
I6I53_RS00315 63973..64170 + 198 Protein_62 TIR domain-containing protein -
I6I53_RS00320 64256..65125 + 870 WP_004999920.1 IS982 family transposase -
I6I53_RS00325 65137..66054 + 918 Protein_64 hypothetical protein -
I6I53_RS00330 66201..66593 - 393 WP_000480876.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
I6I53_RS00335 66669..67979 + 1311 WP_000537298.1 cation diffusion facilitator family transporter -
I6I53_RS00340 67991..68251 + 261 WP_004999929.1 ferrous iron transport protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..120510 120510
- inside IScluster/Tn - - 61391..65125 3734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-76)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8949.11 Da        Isoelectric Point: 4.3747

>T186811 WP_048765058.1 NZ_CP068175:63204-63434 [Acinetobacter ursingii]
MELYFEWDEAKNQKNQKKHDVSFETASLVFEDPLRISIQDRHTNGEERWQTIGMVKGVLMLLVAHTIIDDDECEII

Download         Length: 231 bp

>T186811 NZ_CP089773:71883-72284 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12215.92 Da        Isoelectric Point: 8.4944

>AT186811 WP_004942855.1 NZ_CP068175:63478-63792 [Acinetobacter ursingii]
MSMVRYTRKELNENFSDKQDAEIKRLLAKGTVPDEELDLSDIPEVTDWSHAVRHEQFYRPLKQQTSVRLDADVLAWLKAQ
GKGYQTRMNKILREAMLKDLKNHS

Download         Length: 315 bp

>AT186811 NZ_CP089773:71651-71890 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9Z5H4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T9Z5I3

References