Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1790649..1791133 Replicon chromosome
Accession NZ_CP068170
Organism Erysipelatoclostridium ramosum strain FDAARGOS_1105

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag I6I62_RS08745 Protein ID WP_118264103.1
Coordinates 1790864..1791133 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I6I62_RS08740 Protein ID WP_118264104.1
Coordinates 1790649..1790867 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I62_RS08725 1787388..1788398 + 1011 WP_201899501.1 C40 family peptidase -
I6I62_RS08730 1788479..1789297 + 819 WP_118264106.1 hypothetical protein -
I6I62_RS08735 1789435..1790586 + 1152 WP_118264105.1 hypothetical protein -
I6I62_RS08740 1790649..1790867 + 219 WP_118264104.1 CopG family transcriptional regulator Antitoxin
I6I62_RS08745 1790864..1791133 + 270 WP_118264103.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I62_RS08750 1791428..1792111 + 684 WP_118264102.1 hypothetical protein -
I6I62_RS08755 1792123..1792467 + 345 WP_118264101.1 hypothetical protein -
I6I62_RS08760 1793055..1793957 + 903 WP_201899503.1 hypothetical protein -
I6I62_RS08765 1794252..1794461 + 210 WP_118264099.1 hypothetical protein -
I6I62_RS08770 1794559..1795557 + 999 WP_201899505.1 NERD domain-containing protein -
I6I62_RS08775 1795713..1796066 + 354 WP_201899507.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1786899..1858964 72065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10573.40 Da        Isoelectric Point: 10.3360

>T186809 WP_118264103.1 NZ_CP068170:1790864-1791133 [Erysipelatoclostridium ramosum]
MRYKVVFSKTVLKQLKKMDKYTKLLLINWIENNLDGCDDPRVHGKALSANRSGQWRYRIGDYRLICEIEDNKLVIFALSV
GHRKDVYKR

Download         Length: 270 bp

>T186809 NZ_CP089772:c3791427-3791035 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8339.49 Da        Isoelectric Point: 4.4929

>AT186809 WP_118264104.1 NZ_CP068170:1790649-1790867 [Erysipelatoclostridium ramosum]
MSFSMRLSQEEESLFKSYAKLHGISLSEALKRALLEKIEDEYDINIAESAYKEYLKDPVTYSMDDVKKELGL

Download         Length: 219 bp

>AT186809 NZ_CP089772:c3791702-3791427 [Mycobacterium tuberculosis]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References