Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 278982..279499 Replicon chromosome
Accession NZ_CP068166
Organism Corynebacterium aurimucosum strain FDAARGOS_1109

Toxin (Protein)


Gene name relB Uniprot ID A0A558GJM1
Locus tag I6I66_RS01395 Protein ID WP_070645789.1
Coordinates 279245..279499 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A558GJI2
Locus tag I6I66_RS01390 Protein ID WP_070645790.1
Coordinates 278982..279239 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I66_RS01365 274416..274994 + 579 WP_070731348.1 ATP-binding cassette domain-containing protein -
I6I66_RS01370 274994..275791 + 798 Protein_269 ABC transporter permease -
I6I66_RS01380 277095..277316 + 222 Protein_271 ABC transporter permease -
I6I66_RS01385 277402..278913 + 1512 WP_201828734.1 ATP-binding cassette domain-containing protein -
I6I66_RS01390 278982..279239 + 258 WP_070645790.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
I6I66_RS01395 279245..279499 + 255 WP_070645789.1 Txe/YoeB family addiction module toxin Toxin
I6I66_RS01400 279496..280878 - 1383 WP_070711024.1 protoporphyrinogen oxidase -
I6I66_RS01405 280879..281919 - 1041 WP_201828735.1 uroporphyrinogen decarboxylase -
I6I66_RS01410 281958..282455 - 498 WP_070711023.1 tellurium resistance protein TerC -
I6I66_RS01415 282452..283165 - 714 WP_201828736.1 hypothetical protein -
I6I66_RS01420 283176..284153 - 978 WP_049154862.1 porphobilinogen synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 275829..276671 842


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10167.65 Da        Isoelectric Point: 8.9068

>T186807 WP_070645789.1 NZ_CP068166:279245-279499 [Corynebacterium aurimucosum]
MILSWTEEAWEDYLWWQSHDKKFLKRINNLIKDIARNGNEGIGKPEPLKFELSGFWSRRITEEHRLIYRIKGATIEIAGC
RYHY

Download         Length: 255 bp

>T186807 NZ_CP089772:c3709358-3708930 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9763.76 Da        Isoelectric Point: 4.4280

>AT186807 WP_070645790.1 NZ_CP068166:278982-279239 [Corynebacterium aurimucosum]
MKTMSYSESRARYAEVLQSVVDDREEVIITRNGHESAVIVSFDDYNSLRETAYLLRSPRNAQRLLDSIESLNTGKATEHE
LIEED

Download         Length: 258 bp

>AT186807 NZ_CP089772:c3709604-3709362 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A558GJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A558GJI2

References