186806

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 875612..876129 Replicon chromosome
Accession NZ_CP068165
Organism Corynebacterium aurimucosum strain FDAARGOS_1110

Toxin (Protein)


Gene name relE Uniprot ID C3PKG9
Locus tag I6I67_RS04200 Protein ID WP_010189797.1
Coordinates 875875..876129 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C3PKH0
Locus tag I6I67_RS04195 Protein ID WP_010189796.1
Coordinates 875612..875869 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I67_RS04165 870870..871709 + 840 WP_029158964.1 NAD(P)-dependent oxidoreductase -
I6I67_RS04170 871750..871941 - 192 WP_012714808.1 hypothetical protein -
I6I67_RS04175 871998..872135 - 138 WP_010189784.1 hypothetical protein -
I6I67_RS04180 872354..872932 + 579 WP_010189792.1 ATP-binding cassette domain-containing protein -
I6I67_RS04185 872932..873948 + 1017 WP_010189794.1 hypothetical protein -
I6I67_RS04190 874033..875544 + 1512 WP_010189795.1 ATP-binding cassette domain-containing protein -
I6I67_RS04195 875612..875869 + 258 WP_010189796.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
I6I67_RS04200 875875..876129 + 255 WP_010189797.1 Txe/YoeB family addiction module toxin Toxin
I6I67_RS04205 876324..877706 - 1383 WP_010189798.1 protoporphyrinogen oxidase -
I6I67_RS04210 877707..878747 - 1041 WP_010189800.1 uroporphyrinogen decarboxylase -
I6I67_RS04215 878786..879283 - 498 WP_010189802.1 hypothetical protein -
I6I67_RS04220 879280..879993 - 714 WP_010189804.1 hypothetical protein -
I6I67_RS04225 880004..880981 - 978 WP_010189806.1 porphobilinogen synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10101.68 Da        Isoelectric Point: 9.4833

>T186806 WP_010189797.1 NZ_CP068165:875875-876129 [Corynebacterium aurimucosum]
MILSWTEEAWEDYLWWQAHNKKILKRINSLIKDIARNGNEGIGKPEPLKFELAGFWSRRITEEHRLIYRIKGVTIEIAGC
RYHY

Download         Length: 255 bp

>T186806 NZ_CP089772:3184623-3185066 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9703.66 Da        Isoelectric Point: 4.2497

>AT186806 WP_010189796.1 NZ_CP068165:875612-875869 [Corynebacterium aurimucosum]
MKTMSYSESRARYAEVLQSVVDDREEVIITRSGHESAVIVSLDDYNSLRETAYLLRSPRNAQRLLDSIESLNTGEATEHE
LIEED

Download         Length: 258 bp

>AT186806 NZ_CP089772:3184379-3184636 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N6TJV1

Antitoxin

Source ID Structure
AlphaFold DB C3PKH0

References