Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 952951..953549 Replicon chromosome
Accession NZ_CP068159
Organism Corynebacterium riegelii strain FDAARGOS_1114

Toxin (Protein)


Gene name PumA Uniprot ID A0A2I1V9Y7
Locus tag I6I71_RS04375 Protein ID WP_070482101.1
Coordinates 953241..953549 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D6ZFZ0
Locus tag I6I71_RS04370 Protein ID WP_004009166.1
Coordinates 952951..953244 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I71_RS04325 948106..948315 + 210 WP_201822550.1 hypothetical protein -
I6I71_RS04330 948488..948667 + 180 WP_052205466.1 hypothetical protein -
I6I71_RS04335 948750..948908 + 159 WP_201822552.1 hypothetical protein -
I6I71_RS04340 948916..949593 - 678 WP_201822554.1 TetR/AcrR family transcriptional regulator -
I6I71_RS04345 949685..950914 + 1230 WP_201822556.1 MFS transporter -
I6I71_RS04350 950915..951055 - 141 WP_201822558.1 hypothetical protein -
I6I71_RS04355 951171..951947 - 777 WP_201822560.1 ATP-binding protein -
I6I71_RS04360 952149..952419 + 271 Protein_839 hypothetical protein -
I6I71_RS04365 952520..952732 + 213 Protein_840 IS3 family transposase -
I6I71_RS04370 952951..953244 - 294 WP_004009166.1 putative addiction module antidote protein Antitoxin
I6I71_RS04375 953241..953549 - 309 WP_070482101.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 948916..960151 11235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(6-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11554.24 Da        Isoelectric Point: 9.4826

>T186800 WP_070482101.1 NZ_CP068159:c953549-953241 [Corynebacterium riegelii]
VEIISSSLFDAWLGELKDKHAQRRILYAIARCEAHGRMIGDIKPVGEKVSEMRFHFGPGYRVYYTRLGAITVFLLAGGDK
SSQDKDIRTAQKLAQQVREEQS

Download         Length: 309 bp

>T186800 NZ_CP089772:c3070788-3070372 [Mycobacterium tuberculosis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10610.11 Da        Isoelectric Point: 7.0095

>AT186800 WP_004009166.1 NZ_CP068159:c953244-952951 [Corynebacterium riegelii]
VKEVTFSAFDASKYLDSQEAMNDYLAIALEDGDTKTVQVVLRDIARAHGMSQLAKETQLNRESLYKSLSKDGNPSFAAIT
KIMKALGLKITLATQNA

Download         Length: 294 bp

>AT186800 NZ_CP089772:c3071051-3070785 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I1V9Y7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K1RCQ5

References